Gradients of refractive index in the crystalline lens and transient changes in refraction among patients with diabetes

W. Neil Charman, Adnan, David A. Atchison

Research output: Contribution to journalArticle

6 Citations (Scopus)


Transient hyperopic refractive shifts occur on a timescale of weeks in some patients after initiation of therapy for hyperglycemia, and are usually followed by recovery to the original refraction. Possible lenticular origin of these changes is considered in terms of a paraxial gradient index model. Assuming that the lens thickness and curvatures remain unchanged, as observed in practice, it appears possible to account for initial hyperopic refractive shifts of up to a few diopters by reduction in refractive index near the lens center and alteration in the rate of change between center and surface, so that most of the index change occurs closer to the lens surface. Restoration of the original refraction depends on further change in the refractive index distribution with more gradual changes in refractive index from the lens center to its surface. Modeling limitations are discussed.

Original languageEnglish
Pages (from-to)3033-3042
Number of pages10
JournalBiomedical Optics Express
Issue number12
Publication statusPublished - 1 Dec 2012


ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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