Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions

Giorgio Gimelli, Miguel Angel Pujana, Maria Grazia Patricelli, Silvia Russo, Daniela Giardino, Lidia Larizza, Joseph Cheung, Lluís Armengol, Albert Schinzel, Xavier P. Estivill, Orsetta Zuffardi

Research output: Contribution to journalArticle

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Abstract

Parental submicroscopic genomic inversions have recently been demonstrated to be present in several genomic disorders. These inversions are genomic polymorphisms that facilitate misalignment and abnormal recombination between flanking segmental duplications. Angelman syndrome (AS; MIM 105830) is associated with specific abnormalities of chromosome 15q11-q13, with about 70% of cases being mother-of-origin 4 Mb deletions. We present here evidence that some mothers of AS patients with deletions of the 15q11-q13 region have a heterozygous inversion involving the region that is deleted in the affected offspring. The inversion was detected in the mothers of four of six AS cases with the breakpoint 2-3 (BP2/3) 15q11-q13 deletion, but not in seven mothers of AS due to paternal uniparental disomy (UPD) 15. We have identified variable inversion breakpoints within BP segmental duplications in the inverted AS mothers, as well as in AS deleted patients. Interestingly, the BP2-BP3 region is inverted in the mouse draft genome sequence with respect to the human draft sequence. The BP2-BP3 chromosome 15q11-q13 inversion was detection in four of 44 subjects (9%) of the general population (P < 0.004). The BP2/3 inversion should be an intermediate estate that facilitates the occurrence of 15q11-q13 BP2/3 deletions in the offspring.

Original languageEnglish
Pages (from-to)849-858
Number of pages10
JournalHuman Molecular Genetics
Volume12
Issue number8
DOIs
Publication statusPublished - 15 Apr 2003
Externally publishedYes

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Angelman Syndrome
Human Chromosomes
Mothers
Genomic Segmental Duplications
Chromosome Aberrations
Genetic Recombination
Chromosomes
Genome
Population

ASJC Scopus subject areas

  • Genetics

Cite this

Gimelli, G., Pujana, M. A., Patricelli, M. G., Russo, S., Giardino, D., Larizza, L., ... Zuffardi, O. (2003). Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions. Human Molecular Genetics, 12(8), 849-858. https://doi.org/10.1093/hmg/ddg101

Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions. / Gimelli, Giorgio; Pujana, Miguel Angel; Patricelli, Maria Grazia; Russo, Silvia; Giardino, Daniela; Larizza, Lidia; Cheung, Joseph; Armengol, Lluís; Schinzel, Albert; Estivill, Xavier P.; Zuffardi, Orsetta.

In: Human Molecular Genetics, Vol. 12, No. 8, 15.04.2003, p. 849-858.

Research output: Contribution to journalArticle

Gimelli, G, Pujana, MA, Patricelli, MG, Russo, S, Giardino, D, Larizza, L, Cheung, J, Armengol, L, Schinzel, A, Estivill, XP & Zuffardi, O 2003, 'Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions', Human Molecular Genetics, vol. 12, no. 8, pp. 849-858. https://doi.org/10.1093/hmg/ddg101
Gimelli, Giorgio ; Pujana, Miguel Angel ; Patricelli, Maria Grazia ; Russo, Silvia ; Giardino, Daniela ; Larizza, Lidia ; Cheung, Joseph ; Armengol, Lluís ; Schinzel, Albert ; Estivill, Xavier P. ; Zuffardi, Orsetta. / Genomic inversions of human chromosome 15q11-q13 in mothers of Angelman syndrome patients with class II (BP2/3) deletions. In: Human Molecular Genetics. 2003 ; Vol. 12, No. 8. pp. 849-858.
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