Genome-wide meta-analysis points to CTC1 and ZNf676 as genes regulating telomere homeostasis in humans

Massimo Mangino, Shih Jen Hwang, Timothy D. Spector, Steven Hunt, Masayuki Kimura, Annette L. Fitzpatrick, Lene Christiansen, Inge Petersen, Clara C. Elbers, Tamara Harris, Wei Chen, Sathanur R. Srinivasan, Jeremy D. Kark, Athanase Benetos, Said El shamieh, Sophie Visvikis-Siest, Kaare Christensen, Gerald S. Berenson, Ana M. Valdes, Ana VinuelaMelissa Garcia, Donna K. Arnett, Ulrich Broeckel, Michael A. Province, James S. Pankow, Candace Kammerer, Yongmei Liu, Michael Nalls, Sarah Tishkoff, Fridtjof Thomas, Elad Ziv, Bruce M. Psaty, Joshua C. Bis, Jerome I. Rotter, Kent D. Taylor, Erin Smith, Nicholas J. Schork, Daniel Levy, Abraham Aviv

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116 Citations (Scopus)

Abstract

Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226 individuals from four additional studies. We confirmed previously reported associations with OBFC1 (rs9419958 P = 9.1 × 10-11) and with the telomerase RNA component TERC (rs1317082, P = 1.1 × 10-8). We also identified two novel genomic regions associated with LTL variation that map near a conserved telomere maintenance complex component 1 (CTC1; rs3027234, P = 3.6 × 10-8) on chromosome17p13.1 and zinc finger protein 676 (ZNF676; rs412658, P = 3.3 × 10-8) on 19p12. The minor allele of rs3027234 was associated with both shorter LTL and lower expression of CTC1. Our findings are consistent with the recent observations that point mutations in CTC1 cause short telomeres in both Arabidopsis and humans affected by a rare Mendelian syndrome. Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population.

Original languageEnglish
Article numberdds382
Pages (from-to)5385-5394
Number of pages10
JournalHuman Molecular Genetics
Volume21
Issue number24
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Mangino, M., Hwang, S. J., Spector, T. D., Hunt, S., Kimura, M., Fitzpatrick, A. L., Christiansen, L., Petersen, I., Elbers, C. C., Harris, T., Chen, W., Srinivasan, S. R., Kark, J. D., Benetos, A., El shamieh, S., Visvikis-Siest, S., Christensen, K., Berenson, G. S., Valdes, A. M., ... Aviv, A. (2012). Genome-wide meta-analysis points to CTC1 and ZNf676 as genes regulating telomere homeostasis in humans. Human Molecular Genetics, 21(24), 5385-5394. [dds382]. https://doi.org/10.1093/hmg/dds382