Genome-wide meta-analyses of smoking behaviors in African Americans

S. P. David, A. Hamidovic, G. K. Chen, A. W. Bergen, J. Wessel, J. L. Kasberger, W. M. Brown, S. Petruzella, E. L. Thacker, Y. Kim, M. A. Nalls, G. J. Tranah, Y. J. Sung, C. B. Ambrosone, D. Arnett, E. V. Bandera, D. M. Becker, L. Becker, S. I. Berndt, L. Bernstein & 59 others W. J. Blot, U. Broeckel, S. G. Buxbaum, N. Caporaso, G. Casey, S. J. Chanock, S. L. Deming, W. R. Diver, C. B. Eaton, D. S. Evans, M. K. Evans, M. Fornage, N. Franceschini, T. B. Harris, B. E. Henderson, D. G. Hernandez, B. Hitsman, J. J. Hu, Steven Hunt, S. A. Ingles, E. M. John, R. Kittles, S. Kolb, L. N. Kolonel, L. Le Marchand, Y. Liu, K. K. Lohman, B. McKnight, R. C. Millikan, A. Murphy, C. Neslund-Dudas, S. Nyante, M. Press, B. M. Psaty, D. C. Rao, S. Redline, J. L. Rodriguez-Gil, B. A. Rybicki, L. B. Signorello, A. B. Singleton, J. Smoller, B. Snively, B. Spring, J. L. Stanford, S. S. Strom, G. E. Swan, K. D. Taylor, M. J. Thun, A. F. Wilson, J. S. Witte, Y. Yamamura, L. R. Yanek, K. Yu, W. Zheng, R. G. Ziegler, A. B. Zonderman, E. Jorgenson, C. A. Haiman, H. Furberg

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527A) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (Β=0.040, s.e.=0.007, P=1.84 × 10 -8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.

Original languageEnglish
Article numbere119
JournalTranslational Psychiatry
Volume2
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

African Americans
Meta-Analysis
Smoking
Genome
Single Nucleotide Polymorphism
Genetic Loci
Genome-Wide Association Study
Population Genetics
Smoking Cessation
Tobacco Products
Population
Genes
Tobacco
Chromosomes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

David, S. P., Hamidovic, A., Chen, G. K., Bergen, A. W., Wessel, J., Kasberger, J. L., ... Furberg, H. (2012). Genome-wide meta-analyses of smoking behaviors in African Americans. Translational Psychiatry, 2, [e119]. https://doi.org/10.1038/tp.2012.41

Genome-wide meta-analyses of smoking behaviors in African Americans. / David, S. P.; Hamidovic, A.; Chen, G. K.; Bergen, A. W.; Wessel, J.; Kasberger, J. L.; Brown, W. M.; Petruzella, S.; Thacker, E. L.; Kim, Y.; Nalls, M. A.; Tranah, G. J.; Sung, Y. J.; Ambrosone, C. B.; Arnett, D.; Bandera, E. V.; Becker, D. M.; Becker, L.; Berndt, S. I.; Bernstein, L.; Blot, W. J.; Broeckel, U.; Buxbaum, S. G.; Caporaso, N.; Casey, G.; Chanock, S. J.; Deming, S. L.; Diver, W. R.; Eaton, C. B.; Evans, D. S.; Evans, M. K.; Fornage, M.; Franceschini, N.; Harris, T. B.; Henderson, B. E.; Hernandez, D. G.; Hitsman, B.; Hu, J. J.; Hunt, Steven; Ingles, S. A.; John, E. M.; Kittles, R.; Kolb, S.; Kolonel, L. N.; Le Marchand, L.; Liu, Y.; Lohman, K. K.; McKnight, B.; Millikan, R. C.; Murphy, A.; Neslund-Dudas, C.; Nyante, S.; Press, M.; Psaty, B. M.; Rao, D. C.; Redline, S.; Rodriguez-Gil, J. L.; Rybicki, B. A.; Signorello, L. B.; Singleton, A. B.; Smoller, J.; Snively, B.; Spring, B.; Stanford, J. L.; Strom, S. S.; Swan, G. E.; Taylor, K. D.; Thun, M. J.; Wilson, A. F.; Witte, J. S.; Yamamura, Y.; Yanek, L. R.; Yu, K.; Zheng, W.; Ziegler, R. G.; Zonderman, A. B.; Jorgenson, E.; Haiman, C. A.; Furberg, H.

In: Translational Psychiatry, Vol. 2, e119, 2012.

Research output: Contribution to journalArticle

David, SP, Hamidovic, A, Chen, GK, Bergen, AW, Wessel, J, Kasberger, JL, Brown, WM, Petruzella, S, Thacker, EL, Kim, Y, Nalls, MA, Tranah, GJ, Sung, YJ, Ambrosone, CB, Arnett, D, Bandera, EV, Becker, DM, Becker, L, Berndt, SI, Bernstein, L, Blot, WJ, Broeckel, U, Buxbaum, SG, Caporaso, N, Casey, G, Chanock, SJ, Deming, SL, Diver, WR, Eaton, CB, Evans, DS, Evans, MK, Fornage, M, Franceschini, N, Harris, TB, Henderson, BE, Hernandez, DG, Hitsman, B, Hu, JJ, Hunt, S, Ingles, SA, John, EM, Kittles, R, Kolb, S, Kolonel, LN, Le Marchand, L, Liu, Y, Lohman, KK, McKnight, B, Millikan, RC, Murphy, A, Neslund-Dudas, C, Nyante, S, Press, M, Psaty, BM, Rao, DC, Redline, S, Rodriguez-Gil, JL, Rybicki, BA, Signorello, LB, Singleton, AB, Smoller, J, Snively, B, Spring, B, Stanford, JL, Strom, SS, Swan, GE, Taylor, KD, Thun, MJ, Wilson, AF, Witte, JS, Yamamura, Y, Yanek, LR, Yu, K, Zheng, W, Ziegler, RG, Zonderman, AB, Jorgenson, E, Haiman, CA & Furberg, H 2012, 'Genome-wide meta-analyses of smoking behaviors in African Americans', Translational Psychiatry, vol. 2, e119. https://doi.org/10.1038/tp.2012.41
David SP, Hamidovic A, Chen GK, Bergen AW, Wessel J, Kasberger JL et al. Genome-wide meta-analyses of smoking behaviors in African Americans. Translational Psychiatry. 2012;2. e119. https://doi.org/10.1038/tp.2012.41
David, S. P. ; Hamidovic, A. ; Chen, G. K. ; Bergen, A. W. ; Wessel, J. ; Kasberger, J. L. ; Brown, W. M. ; Petruzella, S. ; Thacker, E. L. ; Kim, Y. ; Nalls, M. A. ; Tranah, G. J. ; Sung, Y. J. ; Ambrosone, C. B. ; Arnett, D. ; Bandera, E. V. ; Becker, D. M. ; Becker, L. ; Berndt, S. I. ; Bernstein, L. ; Blot, W. J. ; Broeckel, U. ; Buxbaum, S. G. ; Caporaso, N. ; Casey, G. ; Chanock, S. J. ; Deming, S. L. ; Diver, W. R. ; Eaton, C. B. ; Evans, D. S. ; Evans, M. K. ; Fornage, M. ; Franceschini, N. ; Harris, T. B. ; Henderson, B. E. ; Hernandez, D. G. ; Hitsman, B. ; Hu, J. J. ; Hunt, Steven ; Ingles, S. A. ; John, E. M. ; Kittles, R. ; Kolb, S. ; Kolonel, L. N. ; Le Marchand, L. ; Liu, Y. ; Lohman, K. K. ; McKnight, B. ; Millikan, R. C. ; Murphy, A. ; Neslund-Dudas, C. ; Nyante, S. ; Press, M. ; Psaty, B. M. ; Rao, D. C. ; Redline, S. ; Rodriguez-Gil, J. L. ; Rybicki, B. A. ; Signorello, L. B. ; Singleton, A. B. ; Smoller, J. ; Snively, B. ; Spring, B. ; Stanford, J. L. ; Strom, S. S. ; Swan, G. E. ; Taylor, K. D. ; Thun, M. J. ; Wilson, A. F. ; Witte, J. S. ; Yamamura, Y. ; Yanek, L. R. ; Yu, K. ; Zheng, W. ; Ziegler, R. G. ; Zonderman, A. B. ; Jorgenson, E. ; Haiman, C. A. ; Furberg, H. / Genome-wide meta-analyses of smoking behaviors in African Americans. In: Translational Psychiatry. 2012 ; Vol. 2.
@article{b104bb18e7df4d538b9b443b47fdccb8,
title = "Genome-wide meta-analyses of smoking behaviors in African Americans",
abstract = "The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527A) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (Β=0.040, s.e.=0.007, P=1.84 × 10 -8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.",
author = "David, {S. P.} and A. Hamidovic and Chen, {G. K.} and Bergen, {A. W.} and J. Wessel and Kasberger, {J. L.} and Brown, {W. M.} and S. Petruzella and Thacker, {E. L.} and Y. Kim and Nalls, {M. A.} and Tranah, {G. J.} and Sung, {Y. J.} and Ambrosone, {C. B.} and D. Arnett and Bandera, {E. V.} and Becker, {D. M.} and L. Becker and Berndt, {S. I.} and L. Bernstein and Blot, {W. J.} and U. Broeckel and Buxbaum, {S. G.} and N. Caporaso and G. Casey and Chanock, {S. J.} and Deming, {S. L.} and Diver, {W. R.} and Eaton, {C. B.} and Evans, {D. S.} and Evans, {M. K.} and M. Fornage and N. Franceschini and Harris, {T. B.} and Henderson, {B. E.} and Hernandez, {D. G.} and B. Hitsman and Hu, {J. J.} and Steven Hunt and Ingles, {S. A.} and John, {E. M.} and R. Kittles and S. Kolb and Kolonel, {L. N.} and {Le Marchand}, L. and Y. Liu and Lohman, {K. K.} and B. McKnight and Millikan, {R. C.} and A. Murphy and C. Neslund-Dudas and S. Nyante and M. Press and Psaty, {B. M.} and Rao, {D. C.} and S. Redline and Rodriguez-Gil, {J. L.} and Rybicki, {B. A.} and Signorello, {L. B.} and Singleton, {A. B.} and J. Smoller and B. Snively and B. Spring and Stanford, {J. L.} and Strom, {S. S.} and Swan, {G. E.} and Taylor, {K. D.} and Thun, {M. J.} and Wilson, {A. F.} and Witte, {J. S.} and Y. Yamamura and Yanek, {L. R.} and K. Yu and W. Zheng and Ziegler, {R. G.} and Zonderman, {A. B.} and E. Jorgenson and Haiman, {C. A.} and H. Furberg",
year = "2012",
doi = "10.1038/tp.2012.41",
language = "English",
volume = "2",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genome-wide meta-analyses of smoking behaviors in African Americans

AU - David, S. P.

AU - Hamidovic, A.

AU - Chen, G. K.

AU - Bergen, A. W.

AU - Wessel, J.

AU - Kasberger, J. L.

AU - Brown, W. M.

AU - Petruzella, S.

AU - Thacker, E. L.

AU - Kim, Y.

AU - Nalls, M. A.

AU - Tranah, G. J.

AU - Sung, Y. J.

AU - Ambrosone, C. B.

AU - Arnett, D.

AU - Bandera, E. V.

AU - Becker, D. M.

AU - Becker, L.

AU - Berndt, S. I.

AU - Bernstein, L.

AU - Blot, W. J.

AU - Broeckel, U.

AU - Buxbaum, S. G.

AU - Caporaso, N.

AU - Casey, G.

AU - Chanock, S. J.

AU - Deming, S. L.

AU - Diver, W. R.

AU - Eaton, C. B.

AU - Evans, D. S.

AU - Evans, M. K.

AU - Fornage, M.

AU - Franceschini, N.

AU - Harris, T. B.

AU - Henderson, B. E.

AU - Hernandez, D. G.

AU - Hitsman, B.

AU - Hu, J. J.

AU - Hunt, Steven

AU - Ingles, S. A.

AU - John, E. M.

AU - Kittles, R.

AU - Kolb, S.

AU - Kolonel, L. N.

AU - Le Marchand, L.

AU - Liu, Y.

AU - Lohman, K. K.

AU - McKnight, B.

AU - Millikan, R. C.

AU - Murphy, A.

AU - Neslund-Dudas, C.

AU - Nyante, S.

AU - Press, M.

AU - Psaty, B. M.

AU - Rao, D. C.

AU - Redline, S.

AU - Rodriguez-Gil, J. L.

AU - Rybicki, B. A.

AU - Signorello, L. B.

AU - Singleton, A. B.

AU - Smoller, J.

AU - Snively, B.

AU - Spring, B.

AU - Stanford, J. L.

AU - Strom, S. S.

AU - Swan, G. E.

AU - Taylor, K. D.

AU - Thun, M. J.

AU - Wilson, A. F.

AU - Witte, J. S.

AU - Yamamura, Y.

AU - Yanek, L. R.

AU - Yu, K.

AU - Zheng, W.

AU - Ziegler, R. G.

AU - Zonderman, A. B.

AU - Jorgenson, E.

AU - Haiman, C. A.

AU - Furberg, H.

PY - 2012

Y1 - 2012

N2 - The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527A) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (Β=0.040, s.e.=0.007, P=1.84 × 10 -8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.

AB - The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527A) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (Β=0.040, s.e.=0.007, P=1.84 × 10 -8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.

UR - http://www.scopus.com/inward/record.url?scp=84861308971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861308971&partnerID=8YFLogxK

U2 - 10.1038/tp.2012.41

DO - 10.1038/tp.2012.41

M3 - Article

VL - 2

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - e119

ER -