Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study

Jemma B. Wilk, Luc Djousse, Donna K. Arnett, Steven Hunt, Michael A. Province, Gerardo Heiss, Richard H. Myers

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A genome-wide scan was performed to identify chromosomal regions related to age at diagnosis of hypertension and to early-onset hypertension in white and African American families from the Hypertension Genetic Epidemiology Network (HyperGEN). Age at diagnosis of hypertension was reported by participants at recruitment and standardized residuals adjusted for sex, study center, and body mass index were created. Participants were classified as having early-onset hypertension if their reported age at diagnosis was before 45 years in whites or before 35 years in African Americans. Variance component linkage analysis was performed for age at diagnosis and an affected sibpair linkage analysis was performed for early-onset hypertension, both implemented in GENEHUNTER. In whites, the heritability of diagnosis age was estimated to be 35% and the maximum LOD score was found on chromosome 1 at 123 cM (LOD = 1.48). The maximum LOD score for early-onset hypertension was located on chromosome 18 at 69 cM (LOD = 1.21). In African Americans, the heritability of age of diagnosis was estimated to be 42% and the maximum LOD scores were found on chromosome 4 at 120 cM (LOD = 2.44) and on chromosome 15 at 60 cM (LOD = 2.31). The maximum LOD for early-onset hypertension in African Americans was also on chromosome 4 at 153 cM (LOD = 2.05) and overlies the mineralocorticoid receptor. Although these results report modest LOD scores, several of these loci have been previously reported to be linked to hypertension and blood pressure, lending further support that genes related to the risk of hypertension may be at these loci.

Original languageEnglish
Pages (from-to)839-844
Number of pages6
JournalAmerican Journal of Hypertension
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

Fingerprint

Molecular Epidemiology
Genome
Hypertension
African Americans
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 15
Mineralocorticoid Receptors
Chromosomes, Human, Pair 1
Body Mass Index
Blood Pressure

Keywords

  • early-onset hypertension
  • Genome scan
  • hypertension diagnosis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study. / Wilk, Jemma B.; Djousse, Luc; Arnett, Donna K.; Hunt, Steven; Province, Michael A.; Heiss, Gerardo; Myers, Richard H.

In: American Journal of Hypertension, Vol. 17, No. 9, 09.2004, p. 839-844.

Research output: Contribution to journalArticle

Wilk, Jemma B. ; Djousse, Luc ; Arnett, Donna K. ; Hunt, Steven ; Province, Michael A. ; Heiss, Gerardo ; Myers, Richard H. / Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study. In: American Journal of Hypertension. 2004 ; Vol. 17, No. 9. pp. 839-844.
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