Genome scan for hypertension in nonobese African Americans: The National Heart, Lung, and Blood Institute Family Blood Pressure Program

Alanna C. Morrison, Richard Cooper, Steven Hunt, Cora E. Lewis, Amy Luke, Thomas H. Mosley, Eric Boerwinkle

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Obesity is an important risk factor for hypertension, but epidemiologic studies provide evidence for the development of hypertension independent of obesity. In addition, the search for hypertension susceptibility genes should prove more informative when applied to a homogeneous subset of patients, such as those that are not obese. For this reason, we sought to identify genomic regions influencing susceptibility to hypertension in a nonobese sample of hypertensive African American families. A genome-wide linkage scan was performed in a sample of 275 African American hypertensive families containing two or more nonobese (body mass index, ≤30 kg/m 2) individuals recruited by Networks of the Family Blood Pressure Program (FBPP). The best evidence for linkage of hypertension among the FBPP African American families was found on chromosome 2 (log of the odds [LOD]= 3.59 at 230 cM). All other chromosomes contained LOD scores less than 2. The African American sibships from the GENOA Network appear to largely contribute to the evidence for linkage on chromosome 2 (LOD = 4.07 at 233 cM). Significant evidence for linkage to hypertension in nonobese African American families was identified on chromosome 2q. These results suggest the presence of genes influencing susceptibility to adiposity-independent hypertension.

Original languageEnglish
Pages (from-to)834-838
Number of pages5
JournalAmerican Journal of Hypertension
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

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National Heart, Lung, and Blood Institute (U.S.)
African Americans
Genome
Blood Pressure
Hypertension
Chromosomes, Human, Pair 2
Obesity
Chromosomes
Adiposity
Genes
Epidemiologic Studies
Body Mass Index

Keywords

  • genetic linkage
  • Hypertension
  • obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Genome scan for hypertension in nonobese African Americans : The National Heart, Lung, and Blood Institute Family Blood Pressure Program. / Morrison, Alanna C.; Cooper, Richard; Hunt, Steven; Lewis, Cora E.; Luke, Amy; Mosley, Thomas H.; Boerwinkle, Eric.

In: American Journal of Hypertension, Vol. 17, No. 9, 09.2004, p. 834-838.

Research output: Contribution to journalArticle

Morrison, Alanna C. ; Cooper, Richard ; Hunt, Steven ; Lewis, Cora E. ; Luke, Amy ; Mosley, Thomas H. ; Boerwinkle, Eric. / Genome scan for hypertension in nonobese African Americans : The National Heart, Lung, and Blood Institute Family Blood Pressure Program. In: American Journal of Hypertension. 2004 ; Vol. 17, No. 9. pp. 834-838.
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