Genetic Susceptibility and the Relationship between Cardiovascular Disease, Immunology, and Psychiatric Illness

Sandra Villafuerte, Melvyn Rubenfire, Ziad Kronfol

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The transfer of information from the genome to the phenotype is complex for both depression and cardiovascular disease (CVD) involving several genetic influences of small size effect, gene-gene and gene-environment interaction. Family studies suggest that 20% of genetic influences are common across depressive symptoms and heart disease. Here we discuss relevant literature on the contribution of genes to both diseases. A polymorphism in the serotonin transporter gene has been associated both with emotion regulation and platelet activation. Other serotonin related genes such as 5-HT2A and TPH2 are associated with psychiatric disorders and cardiovascular risk factors, stress, and inflammation. Genetic variants in stress-related genes have shown differential response to chronic stress, affecting cardiovascular response and mood. Finally, we examine the evidence for a direct link between cytokines, depression, and CVD. A specific focus is on immune mediators that increase risk for future cardiac events and depression and the complex genetic regulation of risk factors.

Original languageEnglish
Title of host publicationPsychiatry and Heart Disease: The Mind, Brain, and Heart
PublisherJohn Wiley and Sons
Pages176-193
Number of pages18
ISBN (Print)9780470685808
DOIs
Publication statusPublished - 31 Jan 2012
Externally publishedYes

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Keywords

  • Complex genetics
  • Cytokines
  • Epistasis
  • HPA axis
  • Immunology
  • Inflammation
  • Pleiotropy
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Villafuerte, S., Rubenfire, M., & Kronfol, Z. (2012). Genetic Susceptibility and the Relationship between Cardiovascular Disease, Immunology, and Psychiatric Illness. In Psychiatry and Heart Disease: The Mind, Brain, and Heart (pp. 176-193). John Wiley and Sons. https://doi.org/10.1002/9780470975138.ch14