Genetic Substructure of Kuwaiti Population Reveals Migration History

Osama Alsmadi, Gaurav Thareja, Fadi Alkayal, Ramakrishnan Rajagopalan, Sumi Elsa John, Prashantha Hebbar, Kazem Behbehani, Thangavel Alphonse Thanaraj

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The State of Kuwait is characterized by settlers from Saudi Arabia, Iran, and other regions of the Arabian Peninsula. The settlements and subsequent admixtures have shaped the genetics of Kuwait. High prevalence of recessive disorders and metabolic syndromes (that increase risk of diabetes) is seen in the peninsula. Understanding the genetic structure of its population will aid studies designed to decipher the underlying causes of these disorders. In this study, we analyzed 572,366 SNP markers from 273 Kuwaiti natives genotyped using the illumina HumanOmniExpress BeadChip. Model-based clustering identified three genetic subgroups with different levels of admixture. A high level of concordance (Mantel test, p=0.0001 for 9999 repeats) was observed between the derived genetic clusters and the surname-based ancestries. Use of Human Genome Diversity Project (HGDP) data to understand admixtures in each group reveals the following: the first group (Kuwait P) is largely of West Asian ancestry, representing Persians with European admixture; the second group (Kuwait S) is predominantly of city-dwelling Saudi Arabian tribe ancestry, and the third group (Kuwait B) includes most of the tent-dwelling Bedouin surnames and is characterized by the presence of 17% African ancestry. Identity by Descent and Homozygosity analyses find Kuwait's population to be heterogeneous (placed between populations that have large amount of ROH and the ones with low ROH) with Kuwait S as highly endogamous, and Kuwait B as diverse. Population differentiation FST estimates place Kuwait P near Asian populations, Kuwait S near Negev Bedouin tribes, and Kuwait B near the Mozabite population. FST distances between the groups are in the range of 0.005 to 0.008; distances of this magnitude are known to cause false positives in disease association studies. Results of analysis for genetic features such as linkage disequilibrium decay patterns conform to Kuwait's geographical location at the nexus of Africa, Europe, and Asia.

Original languageEnglish
Article numbere74913
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - 16 Sep 2013
Externally publishedYes

Fingerprint

Kuwait
Medical problems
Genes
History
history
Population
ancestry
Population Groups
tribal peoples
Nexus
Genetics
Human Genome Project
Saudi Arabia
Genetic Structures
Linkage Disequilibrium
metabolic syndrome
Geographical Locations
linkage disequilibrium
Iran
homozygosity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alsmadi, O., Thareja, G., Alkayal, F., Rajagopalan, R., John, S. E., Hebbar, P., ... Thanaraj, T. A. (2013). Genetic Substructure of Kuwaiti Population Reveals Migration History. PLoS One, 8(9), [e74913]. https://doi.org/10.1371/journal.pone.0074913

Genetic Substructure of Kuwaiti Population Reveals Migration History. / Alsmadi, Osama; Thareja, Gaurav; Alkayal, Fadi; Rajagopalan, Ramakrishnan; John, Sumi Elsa; Hebbar, Prashantha; Behbehani, Kazem; Thanaraj, Thangavel Alphonse.

In: PLoS One, Vol. 8, No. 9, e74913, 16.09.2013.

Research output: Contribution to journalArticle

Alsmadi, O, Thareja, G, Alkayal, F, Rajagopalan, R, John, SE, Hebbar, P, Behbehani, K & Thanaraj, TA 2013, 'Genetic Substructure of Kuwaiti Population Reveals Migration History', PLoS One, vol. 8, no. 9, e74913. https://doi.org/10.1371/journal.pone.0074913
Alsmadi O, Thareja G, Alkayal F, Rajagopalan R, John SE, Hebbar P et al. Genetic Substructure of Kuwaiti Population Reveals Migration History. PLoS One. 2013 Sep 16;8(9). e74913. https://doi.org/10.1371/journal.pone.0074913
Alsmadi, Osama ; Thareja, Gaurav ; Alkayal, Fadi ; Rajagopalan, Ramakrishnan ; John, Sumi Elsa ; Hebbar, Prashantha ; Behbehani, Kazem ; Thanaraj, Thangavel Alphonse. / Genetic Substructure of Kuwaiti Population Reveals Migration History. In: PLoS One. 2013 ; Vol. 8, No. 9.
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