Genetic studies of cation tests and hypertension

R. R. Williams, S. J. Hasstedt, Steven Hunt, L. L. Wu, K. O. Ash

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several tests of cation concentration and transport are being studied among members of large Utah pedigrees as part of a study of the genetic and environmental determinants of essential hypertension. Corrected urinary sodium excretion and plasma sodium concentration correlated well in spouses and siblings (r = 0.21-0.54, p < 0.001), suggesting the effects of shared family environment (e.g., sodium intake). Intraerythrocytic sodium concentration and sodium-lithium countertransport showed no significant correlation in spouses and very significant correlations between siblings and between parents and offspring (r = 0.34-0.58, p < 0.001), suggesting mostly genetic determination. Using maximum likelihood tests of different genetic models, both sodium-lithium countertransport and intraerythrocytic sodium showed predominantly polygenic determination (H2 = 70%) and some possible major gene determinants (H2 = 18-25%) for a total heritability of 89 to 95% for these characteristics. These data suggest both genes and shared family environment contribute to the familiality of cation tests. They also illustrate the need and utility of quantitative methods for objective analysis of pedigree data.

Original languageEnglish
JournalHypertension
Volume10
Issue number5 II SUPPl.
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Cations
Sodium
Hypertension
Pedigree
Spouses
Lithium
Siblings
Genetic Models
Genes
Parents

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Williams, R. R., Hasstedt, S. J., Hunt, S., Wu, L. L., & Ash, K. O. (1987). Genetic studies of cation tests and hypertension. Hypertension, 10(5 II SUPPl.).

Genetic studies of cation tests and hypertension. / Williams, R. R.; Hasstedt, S. J.; Hunt, Steven; Wu, L. L.; Ash, K. O.

In: Hypertension, Vol. 10, No. 5 II SUPPl., 1987.

Research output: Contribution to journalArticle

Williams, RR, Hasstedt, SJ, Hunt, S, Wu, LL & Ash, KO 1987, 'Genetic studies of cation tests and hypertension', Hypertension, vol. 10, no. 5 II SUPPl..
Williams RR, Hasstedt SJ, Hunt S, Wu LL, Ash KO. Genetic studies of cation tests and hypertension. Hypertension. 1987;10(5 II SUPPl.).
Williams, R. R. ; Hasstedt, S. J. ; Hunt, Steven ; Wu, L. L. ; Ash, K. O. / Genetic studies of cation tests and hypertension. In: Hypertension. 1987 ; Vol. 10, No. 5 II SUPPl.
@article{7edd3db3ec6446c4b9a54d665cfaae89,
title = "Genetic studies of cation tests and hypertension",
abstract = "Several tests of cation concentration and transport are being studied among members of large Utah pedigrees as part of a study of the genetic and environmental determinants of essential hypertension. Corrected urinary sodium excretion and plasma sodium concentration correlated well in spouses and siblings (r = 0.21-0.54, p < 0.001), suggesting the effects of shared family environment (e.g., sodium intake). Intraerythrocytic sodium concentration and sodium-lithium countertransport showed no significant correlation in spouses and very significant correlations between siblings and between parents and offspring (r = 0.34-0.58, p < 0.001), suggesting mostly genetic determination. Using maximum likelihood tests of different genetic models, both sodium-lithium countertransport and intraerythrocytic sodium showed predominantly polygenic determination (H2 = 70{\%}) and some possible major gene determinants (H2 = 18-25{\%}) for a total heritability of 89 to 95{\%} for these characteristics. These data suggest both genes and shared family environment contribute to the familiality of cation tests. They also illustrate the need and utility of quantitative methods for objective analysis of pedigree data.",
author = "Williams, {R. R.} and Hasstedt, {S. J.} and Steven Hunt and Wu, {L. L.} and Ash, {K. O.}",
year = "1987",
language = "English",
volume = "10",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "5 II SUPPl.",

}

TY - JOUR

T1 - Genetic studies of cation tests and hypertension

AU - Williams, R. R.

AU - Hasstedt, S. J.

AU - Hunt, Steven

AU - Wu, L. L.

AU - Ash, K. O.

PY - 1987

Y1 - 1987

N2 - Several tests of cation concentration and transport are being studied among members of large Utah pedigrees as part of a study of the genetic and environmental determinants of essential hypertension. Corrected urinary sodium excretion and plasma sodium concentration correlated well in spouses and siblings (r = 0.21-0.54, p < 0.001), suggesting the effects of shared family environment (e.g., sodium intake). Intraerythrocytic sodium concentration and sodium-lithium countertransport showed no significant correlation in spouses and very significant correlations between siblings and between parents and offspring (r = 0.34-0.58, p < 0.001), suggesting mostly genetic determination. Using maximum likelihood tests of different genetic models, both sodium-lithium countertransport and intraerythrocytic sodium showed predominantly polygenic determination (H2 = 70%) and some possible major gene determinants (H2 = 18-25%) for a total heritability of 89 to 95% for these characteristics. These data suggest both genes and shared family environment contribute to the familiality of cation tests. They also illustrate the need and utility of quantitative methods for objective analysis of pedigree data.

AB - Several tests of cation concentration and transport are being studied among members of large Utah pedigrees as part of a study of the genetic and environmental determinants of essential hypertension. Corrected urinary sodium excretion and plasma sodium concentration correlated well in spouses and siblings (r = 0.21-0.54, p < 0.001), suggesting the effects of shared family environment (e.g., sodium intake). Intraerythrocytic sodium concentration and sodium-lithium countertransport showed no significant correlation in spouses and very significant correlations between siblings and between parents and offspring (r = 0.34-0.58, p < 0.001), suggesting mostly genetic determination. Using maximum likelihood tests of different genetic models, both sodium-lithium countertransport and intraerythrocytic sodium showed predominantly polygenic determination (H2 = 70%) and some possible major gene determinants (H2 = 18-25%) for a total heritability of 89 to 95% for these characteristics. These data suggest both genes and shared family environment contribute to the familiality of cation tests. They also illustrate the need and utility of quantitative methods for objective analysis of pedigree data.

UR - http://www.scopus.com/inward/record.url?scp=0023604902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023604902&partnerID=8YFLogxK

M3 - Article

VL - 10

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 5 II SUPPl.

ER -