Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies

Hua Tang, Tom Quertermous, Beatriz Rodriguez, Sharon L R Kardia, Xiaofeng Zhu, Andrew Brown, James S. Pankow, Michael A. Province, Steven Hunt, Eric Boerwinkle, Nicholas J. Schork, Neil J. Risch

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

We have analyzed genetic data for 326 microsatellite markers that were typed uniformly in a large multiethnic population-based sample of individuals as part of a study of the genetics of hypertension (Family Blood Pressure Program). Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. Genetic cluster analysis of the microsatellite markers produced four major clusters, which showed near-perfect correspondence with the four self-reported race/ethnicity categories. Of 3,636 subjects of varying race/ethnicity, only 5 (0.14%) showed genetic cluster membership different from their self-identified race/ethnicity. On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. Implications of this genetic structure for case-control association studies are discussed.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalAmerican Journal of Human Genetics
Volume76
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

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Genetic Structures
Case-Control Studies
Microsatellite Repeats
Taiwan
Hispanic Americans
Ethnic Groups
African Americans
Population
Cluster Analysis
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Genetics

Cite this

Tang, H., Quertermous, T., Rodriguez, B., Kardia, S. L. R., Zhu, X., Brown, A., ... Risch, N. J. (2005). Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. American Journal of Human Genetics, 76(2), 268-275. https://doi.org/10.1086/427888

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. / Tang, Hua; Quertermous, Tom; Rodriguez, Beatriz; Kardia, Sharon L R; Zhu, Xiaofeng; Brown, Andrew; Pankow, James S.; Province, Michael A.; Hunt, Steven; Boerwinkle, Eric; Schork, Nicholas J.; Risch, Neil J.

In: American Journal of Human Genetics, Vol. 76, No. 2, 02.2005, p. 268-275.

Research output: Contribution to journalArticle

Tang, H, Quertermous, T, Rodriguez, B, Kardia, SLR, Zhu, X, Brown, A, Pankow, JS, Province, MA, Hunt, S, Boerwinkle, E, Schork, NJ & Risch, NJ 2005, 'Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies', American Journal of Human Genetics, vol. 76, no. 2, pp. 268-275. https://doi.org/10.1086/427888
Tang, Hua ; Quertermous, Tom ; Rodriguez, Beatriz ; Kardia, Sharon L R ; Zhu, Xiaofeng ; Brown, Andrew ; Pankow, James S. ; Province, Michael A. ; Hunt, Steven ; Boerwinkle, Eric ; Schork, Nicholas J. ; Risch, Neil J. / Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. In: American Journal of Human Genetics. 2005 ; Vol. 76, No. 2. pp. 268-275.
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