Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer

Julie Decock, R. Paridaens, S. Ye

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer.

Original languageEnglish
Pages (from-to)197-211
Number of pages15
JournalClinical Genetics
Volume73
Issue number3
DOIs
Publication statusPublished - 1 Mar 2008
Externally publishedYes

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Keywords

  • Breast cancer
  • Colorectal cancer
  • Lung cancer
  • Matrix metalloproteinases
  • Polymorphism SNP
  • Survival
  • Susceptibility

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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