Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa

Khalid Moumad, Jesus Lascorz, Melanie Bevier, Meriem Khyatti, Moulay Mustapha Ennaji, Abdellatif Benider, Stefanie Huhn, Shun Lu, Lotfi Chouchane, Marilys Corbex, Kari Hemminki, Asta Försti

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus2associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid2inducible gene I2like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95% confidence interval [95% CI] 1.1122.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95% CI 0.5220.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95% CI 0.5120.98; P = 0.04) were associated with the risk of NPC. An 18% increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (ptrend = 8.2×10-4). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies.

Original languageEnglish
Pages (from-to)971-977
Number of pages7
JournalG3: Genes, Genomes, Genetics
Volume3
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Northern Africa
Genetic Polymorphisms
Single Nucleotide Polymorphism
Genes
Odds Ratio
Confidence Intervals
C-Type Lectins
Pattern Recognition Receptors
Toll-Like Receptors
Neoplasms
Alleles
Nasopharyngeal carcinoma
Viruses
Infection

Keywords

  • Epstein-barr virus
  • Host innate immune sensors
  • Nasopharyngeal carcinoma
  • North Africa
  • SNPs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Moumad, K., Lascorz, J., Bevier, M., Khyatti, M., Ennaji, M. M., Benider, A., ... Försti, A. (2013). Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa. G3: Genes, Genomes, Genetics, 3(6), 971-977. https://doi.org/10.1534/g3.112.005371

Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa. / Moumad, Khalid; Lascorz, Jesus; Bevier, Melanie; Khyatti, Meriem; Ennaji, Moulay Mustapha; Benider, Abdellatif; Huhn, Stefanie; Lu, Shun; Chouchane, Lotfi; Corbex, Marilys; Hemminki, Kari; Försti, Asta.

In: G3: Genes, Genomes, Genetics, Vol. 3, No. 6, 2013, p. 971-977.

Research output: Contribution to journalArticle

Moumad, K, Lascorz, J, Bevier, M, Khyatti, M, Ennaji, MM, Benider, A, Huhn, S, Lu, S, Chouchane, L, Corbex, M, Hemminki, K & Försti, A 2013, 'Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa', G3: Genes, Genomes, Genetics, vol. 3, no. 6, pp. 971-977. https://doi.org/10.1534/g3.112.005371
Moumad, Khalid ; Lascorz, Jesus ; Bevier, Melanie ; Khyatti, Meriem ; Ennaji, Moulay Mustapha ; Benider, Abdellatif ; Huhn, Stefanie ; Lu, Shun ; Chouchane, Lotfi ; Corbex, Marilys ; Hemminki, Kari ; Försti, Asta. / Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa. In: G3: Genes, Genomes, Genetics. 2013 ; Vol. 3, No. 6. pp. 971-977.
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abstract = "Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus2associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid2inducible gene I2like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95{\%} confidence interval [95{\%} CI] 1.1122.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95{\%} CI 0.5220.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95{\%} CI 0.5120.98; P = 0.04) were associated with the risk of NPC. An 18{\%} increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (ptrend = 8.2×10-4). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies.",
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