Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans

Kelly L. Onions, Steven Hunt, Mark P. Rutkowski, Charles A. Klanke, Yan Ru Su, Max Reif, Anil G. Menon

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Increased body mass index (BMI) has been correlated with increased blood pressure in human populations. To examine the role of the leptin gene (OB) in essential hypertension in African Americans, we performed affected sib pair analysis on a set of 103 hypertensive African American sibships using four highly polymorphic markers at the human leptin locus. No evidence of linkage was detected between these markers and the phenotype of essential hypertension either in these sibships or in a severely obese subset of 46 sibships in which each sibling had a BMI ≤85th percentile for the US population. Using BMI rather than hypertension as a quantitative trait, we found significant linkage for the marker D7S504 (P=0.029) but not for the other markers. Significance strengthened in the overweight subsel of sibships for this marker (P=0.001), and there was a trend of lower P values for the other three markers. However, multipoint analysis with the use of all four markers simultaneously to estimate linkage between BMI and the leptin locus did not demonstrate a statistically significant relationship. Analysis of the coding region of the leptin gene (exons 2 and 3) by single-strand conformational polymorphism revealed a rare Ile-Val polymorphism at amino acid 45 but revealed no other alterations. These results suggest that the OB gene is not a major contributor to the phenotype of essential hypertension in African Americans, although a minor contribution to the phenotype of extreme obesity in this group cannot be ruled out.

Original languageEnglish
Pages (from-to)1230-1234
Number of pages5
JournalHypertension
Volume31
Issue number6
Publication statusPublished - Jun 1998
Externally publishedYes

Fingerprint

Leptin
Genetic Markers
African Americans
Body Mass Index
Hypertension
Phenotype
isoleucylvaline
Genes
Population
Siblings
Exons
Obesity
Blood Pressure
Amino Acids
Essential Hypertension

Keywords

  • Body mass index
  • Hypertension, essential
  • Leptin
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Onions, K. L., Hunt, S., Rutkowski, M. P., Klanke, C. A., Su, Y. R., Reif, M., & Menon, A. G. (1998). Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension, 31(6), 1230-1234.

Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. / Onions, Kelly L.; Hunt, Steven; Rutkowski, Mark P.; Klanke, Charles A.; Su, Yan Ru; Reif, Max; Menon, Anil G.

In: Hypertension, Vol. 31, No. 6, 06.1998, p. 1230-1234.

Research output: Contribution to journalArticle

Onions, KL, Hunt, S, Rutkowski, MP, Klanke, CA, Su, YR, Reif, M & Menon, AG 1998, 'Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans', Hypertension, vol. 31, no. 6, pp. 1230-1234.
Onions KL, Hunt S, Rutkowski MP, Klanke CA, Su YR, Reif M et al. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension. 1998 Jun;31(6):1230-1234.
Onions, Kelly L. ; Hunt, Steven ; Rutkowski, Mark P. ; Klanke, Charles A. ; Su, Yan Ru ; Reif, Max ; Menon, Anil G. / Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. In: Hypertension. 1998 ; Vol. 31, No. 6. pp. 1230-1234.
@article{f55fb846246248adba449ad457766f70,
title = "Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans",
abstract = "Increased body mass index (BMI) has been correlated with increased blood pressure in human populations. To examine the role of the leptin gene (OB) in essential hypertension in African Americans, we performed affected sib pair analysis on a set of 103 hypertensive African American sibships using four highly polymorphic markers at the human leptin locus. No evidence of linkage was detected between these markers and the phenotype of essential hypertension either in these sibships or in a severely obese subset of 46 sibships in which each sibling had a BMI ≤85th percentile for the US population. Using BMI rather than hypertension as a quantitative trait, we found significant linkage for the marker D7S504 (P=0.029) but not for the other markers. Significance strengthened in the overweight subsel of sibships for this marker (P=0.001), and there was a trend of lower P values for the other three markers. However, multipoint analysis with the use of all four markers simultaneously to estimate linkage between BMI and the leptin locus did not demonstrate a statistically significant relationship. Analysis of the coding region of the leptin gene (exons 2 and 3) by single-strand conformational polymorphism revealed a rare Ile-Val polymorphism at amino acid 45 but revealed no other alterations. These results suggest that the OB gene is not a major contributor to the phenotype of essential hypertension in African Americans, although a minor contribution to the phenotype of extreme obesity in this group cannot be ruled out.",
keywords = "Body mass index, Hypertension, essential, Leptin, Obesity",
author = "Onions, {Kelly L.} and Steven Hunt and Rutkowski, {Mark P.} and Klanke, {Charles A.} and Su, {Yan Ru} and Max Reif and Menon, {Anil G.}",
year = "1998",
month = "6",
language = "English",
volume = "31",
pages = "1230--1234",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans

AU - Onions, Kelly L.

AU - Hunt, Steven

AU - Rutkowski, Mark P.

AU - Klanke, Charles A.

AU - Su, Yan Ru

AU - Reif, Max

AU - Menon, Anil G.

PY - 1998/6

Y1 - 1998/6

N2 - Increased body mass index (BMI) has been correlated with increased blood pressure in human populations. To examine the role of the leptin gene (OB) in essential hypertension in African Americans, we performed affected sib pair analysis on a set of 103 hypertensive African American sibships using four highly polymorphic markers at the human leptin locus. No evidence of linkage was detected between these markers and the phenotype of essential hypertension either in these sibships or in a severely obese subset of 46 sibships in which each sibling had a BMI ≤85th percentile for the US population. Using BMI rather than hypertension as a quantitative trait, we found significant linkage for the marker D7S504 (P=0.029) but not for the other markers. Significance strengthened in the overweight subsel of sibships for this marker (P=0.001), and there was a trend of lower P values for the other three markers. However, multipoint analysis with the use of all four markers simultaneously to estimate linkage between BMI and the leptin locus did not demonstrate a statistically significant relationship. Analysis of the coding region of the leptin gene (exons 2 and 3) by single-strand conformational polymorphism revealed a rare Ile-Val polymorphism at amino acid 45 but revealed no other alterations. These results suggest that the OB gene is not a major contributor to the phenotype of essential hypertension in African Americans, although a minor contribution to the phenotype of extreme obesity in this group cannot be ruled out.

AB - Increased body mass index (BMI) has been correlated with increased blood pressure in human populations. To examine the role of the leptin gene (OB) in essential hypertension in African Americans, we performed affected sib pair analysis on a set of 103 hypertensive African American sibships using four highly polymorphic markers at the human leptin locus. No evidence of linkage was detected between these markers and the phenotype of essential hypertension either in these sibships or in a severely obese subset of 46 sibships in which each sibling had a BMI ≤85th percentile for the US population. Using BMI rather than hypertension as a quantitative trait, we found significant linkage for the marker D7S504 (P=0.029) but not for the other markers. Significance strengthened in the overweight subsel of sibships for this marker (P=0.001), and there was a trend of lower P values for the other three markers. However, multipoint analysis with the use of all four markers simultaneously to estimate linkage between BMI and the leptin locus did not demonstrate a statistically significant relationship. Analysis of the coding region of the leptin gene (exons 2 and 3) by single-strand conformational polymorphism revealed a rare Ile-Val polymorphism at amino acid 45 but revealed no other alterations. These results suggest that the OB gene is not a major contributor to the phenotype of essential hypertension in African Americans, although a minor contribution to the phenotype of extreme obesity in this group cannot be ruled out.

KW - Body mass index

KW - Hypertension, essential

KW - Leptin

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=0031866518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031866518&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 1230

EP - 1234

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -