Genetic landscape of the people of India: A canvas for disease gene exploration

Samir K. Brahmachari, Partha P. Majumder, Mitali Mukerji, Saman Habib, Debasis Dash, Kunal Ray, Samira Bahl, Lalji Singh, Abhay Sharma, Susanta Roychoudhury, G. R. Chandak, K. Thangaraj, D. Parmar, Shantanu Sengupta, Dwaipayan Bharadwaj, Srikanta K. Rath, Jagmohan Singh, Ganga Nath Jha, Komal Virdi, V. R. RaoSwapnil Sinha, Ashok Singh, Amit K. Mitra, Shrawan K. Mishra, Qadar Pasha, Sridhar Sivasubbu, Rajesh Pandey, Aradhita Baral, Prashant K. Singh, Amitabh Sharma, Jitender Kumar, Tsering Stobdan, Yasha Bhasin, Chitra Chauhan, Ashiq Hussain, Elyanambi Sundaramoorthy, S. P. Singh, Arun Bandyopadhyay, Krishanu Dasgupta, A. K. Reddy, Charles J. Spurgeon, M. Mohd Idris, Vinay Khanna, Alok Dhawan, Mohini Anand, R. Shankar, R. S. Bharti, Madhu Singh, M. Chidambaram, Ikhlak Ahmed

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Analyses of frequency profiles of markers on disease or drug-response related genes in diverse populations are important for the dissection of common diseases. We report the results of analyses of data on 405 SNPs from 75 such genes and a 5.2 Mb chromosome, 22 genomic region in 1871 individuals from diverse 55 endogamous Indian populations. These include 32 large (> 10 million individuals) and 23 isolated populations, representing a large fraction of the people of India. We observe high levels of genetic divergence between groups of populations that cluster largely on the basis of ethnicity and language. Indian populations not only overlap with the diversity of HapMap populations, but also contain population groups that are genetically distinct. These data and results are useful for addressing stratification and study design issues in complex traits especially for heterogeneous populations.

Original languageEnglish
Pages (from-to)3-20
Number of pages18
JournalJournal of Genetics
Volume87
Issue number1
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

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Keywords

  • Asia
  • Complex disease
  • HapMap
  • Indian genome variation
  • Pharmacogenomics
  • Polymorphism
  • SNP

ASJC Scopus subject areas

  • Genetics

Cite this

Brahmachari, S. K., Majumder, P. P., Mukerji, M., Habib, S., Dash, D., Ray, K., Bahl, S., Singh, L., Sharma, A., Roychoudhury, S., Chandak, G. R., Thangaraj, K., Parmar, D., Sengupta, S., Bharadwaj, D., Rath, S. K., Singh, J., Jha, G. N., Virdi, K., ... Ahmed, I. (2008). Genetic landscape of the people of India: A canvas for disease gene exploration. Journal of Genetics, 87(1), 3-20. https://doi.org/10.1007/s12041-008-0002-x