Genetic landscape of the people of India: A canvas for disease gene exploration

Samir K. Brahmachari, Partha P. Majumder, Mitali Mukerji, Saman Habib, Debasis Dash, Kunal Ray, Samira Bahl, Lalji Singh, Abhay Sharma, Susanta Roychoudhury, G. R. Chandak, K. Thangaraj, D. Parmar, Shantanu Sengupta, Dwaipayan Bharadwaj, Srikanta K. Rath, Jagmohan Singh, Ganga Nath Jha, Komal Virdi, V. R. RaoSwapnil Sinha, Ashok Singh, Amit K. Mitra, Shrawan K. Mishra, Qadar Pasha, Sridhar Sivasubbu, Rajesh Pandey, Aradhita Baral, Prashant K. Singh, Amitabh Sharma, Jitender Kumar, Tsering Stobdan, Yasha Bhasin, Chitra Chauhan, Ashiq Hussain, Elyanambi Sundaramoorthy, S. P. Singh, Arun Bandyopadhyay, Krishanu Dasgupta, A. K. Reddy, Charles J. Spurgeon, M. Mohd Idris, Vinay Khanna, Alok Dhawan, Mohini Anand, R. Shankar, R. S. Bharti, Madhu Singh, M. Chidambaram, Ikhlak Ahmed

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Analyses of frequency profiles of markers on disease or drug-response related genes in diverse populations are important for the dissection of common diseases. We report the results of analyses of data on 405 SNPs from 75 such genes and a 5.2 Mb chromosome, 22 genomic region in 1871 individuals from diverse 55 endogamous Indian populations. These include 32 large (> 10 million individuals) and 23 isolated populations, representing a large fraction of the people of India. We observe high levels of genetic divergence between groups of populations that cluster largely on the basis of ethnicity and language. Indian populations not only overlap with the diversity of HapMap populations, but also contain population groups that are genetically distinct. These data and results are useful for addressing stratification and study design issues in complex traits especially for heterogeneous populations.

Original languageEnglish
Pages (from-to)3-20
Number of pages18
JournalJournal of Genetics
Volume87
Issue number1
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Fingerprint

India
Population
Genes
HapMap Project
Chromosomes, Human, Pair 22
Single Nucleotide Polymorphism
Dissection
Language
Pharmaceutical Preparations

Keywords

  • Asia
  • Complex disease
  • HapMap
  • Indian genome variation
  • Pharmacogenomics
  • Polymorphism
  • SNP

ASJC Scopus subject areas

  • Genetics

Cite this

Brahmachari, S. K., Majumder, P. P., Mukerji, M., Habib, S., Dash, D., Ray, K., ... Ahmed, I. (2008). Genetic landscape of the people of India: A canvas for disease gene exploration. Journal of Genetics, 87(1), 3-20. https://doi.org/10.1007/s12041-008-0002-x

Genetic landscape of the people of India : A canvas for disease gene exploration. / Brahmachari, Samir K.; Majumder, Partha P.; Mukerji, Mitali; Habib, Saman; Dash, Debasis; Ray, Kunal; Bahl, Samira; Singh, Lalji; Sharma, Abhay; Roychoudhury, Susanta; Chandak, G. R.; Thangaraj, K.; Parmar, D.; Sengupta, Shantanu; Bharadwaj, Dwaipayan; Rath, Srikanta K.; Singh, Jagmohan; Jha, Ganga Nath; Virdi, Komal; Rao, V. R.; Sinha, Swapnil; Singh, Ashok; Mitra, Amit K.; Mishra, Shrawan K.; Pasha, Qadar; Sivasubbu, Sridhar; Pandey, Rajesh; Baral, Aradhita; Singh, Prashant K.; Sharma, Amitabh; Kumar, Jitender; Stobdan, Tsering; Bhasin, Yasha; Chauhan, Chitra; Hussain, Ashiq; Sundaramoorthy, Elyanambi; Singh, S. P.; Bandyopadhyay, Arun; Dasgupta, Krishanu; Reddy, A. K.; Spurgeon, Charles J.; Idris, M. Mohd; Khanna, Vinay; Dhawan, Alok; Anand, Mohini; Shankar, R.; Bharti, R. S.; Singh, Madhu; Chidambaram, M.; Ahmed, Ikhlak.

In: Journal of Genetics, Vol. 87, No. 1, 04.2008, p. 3-20.

Research output: Contribution to journalArticle

Brahmachari, SK, Majumder, PP, Mukerji, M, Habib, S, Dash, D, Ray, K, Bahl, S, Singh, L, Sharma, A, Roychoudhury, S, Chandak, GR, Thangaraj, K, Parmar, D, Sengupta, S, Bharadwaj, D, Rath, SK, Singh, J, Jha, GN, Virdi, K, Rao, VR, Sinha, S, Singh, A, Mitra, AK, Mishra, SK, Pasha, Q, Sivasubbu, S, Pandey, R, Baral, A, Singh, PK, Sharma, A, Kumar, J, Stobdan, T, Bhasin, Y, Chauhan, C, Hussain, A, Sundaramoorthy, E, Singh, SP, Bandyopadhyay, A, Dasgupta, K, Reddy, AK, Spurgeon, CJ, Idris, MM, Khanna, V, Dhawan, A, Anand, M, Shankar, R, Bharti, RS, Singh, M, Chidambaram, M & Ahmed, I 2008, 'Genetic landscape of the people of India: A canvas for disease gene exploration', Journal of Genetics, vol. 87, no. 1, pp. 3-20. https://doi.org/10.1007/s12041-008-0002-x
Brahmachari SK, Majumder PP, Mukerji M, Habib S, Dash D, Ray K et al. Genetic landscape of the people of India: A canvas for disease gene exploration. Journal of Genetics. 2008 Apr;87(1):3-20. https://doi.org/10.1007/s12041-008-0002-x
Brahmachari, Samir K. ; Majumder, Partha P. ; Mukerji, Mitali ; Habib, Saman ; Dash, Debasis ; Ray, Kunal ; Bahl, Samira ; Singh, Lalji ; Sharma, Abhay ; Roychoudhury, Susanta ; Chandak, G. R. ; Thangaraj, K. ; Parmar, D. ; Sengupta, Shantanu ; Bharadwaj, Dwaipayan ; Rath, Srikanta K. ; Singh, Jagmohan ; Jha, Ganga Nath ; Virdi, Komal ; Rao, V. R. ; Sinha, Swapnil ; Singh, Ashok ; Mitra, Amit K. ; Mishra, Shrawan K. ; Pasha, Qadar ; Sivasubbu, Sridhar ; Pandey, Rajesh ; Baral, Aradhita ; Singh, Prashant K. ; Sharma, Amitabh ; Kumar, Jitender ; Stobdan, Tsering ; Bhasin, Yasha ; Chauhan, Chitra ; Hussain, Ashiq ; Sundaramoorthy, Elyanambi ; Singh, S. P. ; Bandyopadhyay, Arun ; Dasgupta, Krishanu ; Reddy, A. K. ; Spurgeon, Charles J. ; Idris, M. Mohd ; Khanna, Vinay ; Dhawan, Alok ; Anand, Mohini ; Shankar, R. ; Bharti, R. S. ; Singh, Madhu ; Chidambaram, M. ; Ahmed, Ikhlak. / Genetic landscape of the people of India : A canvas for disease gene exploration. In: Journal of Genetics. 2008 ; Vol. 87, No. 1. pp. 3-20.
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AU - Mukerji, Mitali

AU - Habib, Saman

AU - Dash, Debasis

AU - Ray, Kunal

AU - Bahl, Samira

AU - Singh, Lalji

AU - Sharma, Abhay

AU - Roychoudhury, Susanta

AU - Chandak, G. R.

AU - Thangaraj, K.

AU - Parmar, D.

AU - Sengupta, Shantanu

AU - Bharadwaj, Dwaipayan

AU - Rath, Srikanta K.

AU - Singh, Jagmohan

AU - Jha, Ganga Nath

AU - Virdi, Komal

AU - Rao, V. R.

AU - Sinha, Swapnil

AU - Singh, Ashok

AU - Mitra, Amit K.

AU - Mishra, Shrawan K.

AU - Pasha, Qadar

AU - Sivasubbu, Sridhar

AU - Pandey, Rajesh

AU - Baral, Aradhita

AU - Singh, Prashant K.

AU - Sharma, Amitabh

AU - Kumar, Jitender

AU - Stobdan, Tsering

AU - Bhasin, Yasha

AU - Chauhan, Chitra

AU - Hussain, Ashiq

AU - Sundaramoorthy, Elyanambi

AU - Singh, S. P.

AU - Bandyopadhyay, Arun

AU - Dasgupta, Krishanu

AU - Reddy, A. K.

AU - Spurgeon, Charles J.

AU - Idris, M. Mohd

AU - Khanna, Vinay

AU - Dhawan, Alok

AU - Anand, Mohini

AU - Shankar, R.

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KW - Indian genome variation

KW - Pharmacogenomics

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