Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites

Hamza Babiker, Lisa Ranford-Cartwright, Ali Sultan, Gwiria Satti, David Walliker

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was foundto be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume88
Issue number3
DOIs
Publication statusPublished - 1994
Externally publishedYes

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Chloroquine
Plasmodium falciparum
Parasites
Recurrence
Merozoite Surface Protein 1
Merozoites
Parasitic Diseases
Surface Antigens
Infection
Alleles
Genes
Therapeutics

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Medicine(all)

Cite this

Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites. / Babiker, Hamza; Ranford-Cartwright, Lisa; Sultan, Ali; Satti, Gwiria; Walliker, David.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 88, No. 3, 1994, p. 328-331.

Research output: Contribution to journalArticle

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