Genetic effect on blood pressure is modulated by age the hypertension genetic epidemiology network study

Gang Shi, Chi C. Gu, Aldi T. Kraja, Donna K. Arnett, Richard H. Myers, James S. Pankow, Steven Hunt, Dabeeru C. Rao

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in the Hypertension Genetic Epidemiology Network. We investigated the role of gene-age interactions using a recently developed variance components method that incorporates age variation in genetic effects. Substantially improved linkage evidence, in terms of both the number of linkage peaks and their significance levels, was observed. Twenty-six linkage peaks were identified with maximum logarithm of odds scores ranging between 3.0 and 4.6, 15 of which were cross-validated by the literature. The chromosomal region 1p36 that showed the highest logarithm of odds score in our study was found to be supported by evidence from 3 studies. The new method also led to vastly improved validation across ethnic groups. Ten of the 15 supported linkage peaks were cross-validated between 2 different ethnic groups, and 2 peaks on chromosomal region 1q31 and 16p11 were validated in 3 ethnic groups. In conclusion, this investigation demonstrates that genetic effects on blood pressure vary by age. The improved genetic linkage results presented here should help to identify the specific genetic variants that explain the observed results.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalHypertension
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Molecular Epidemiology
Ethnic Groups
Blood Pressure
Hypertension
Genetic Linkage
Genome
Genes

Keywords

  • Blood pressure
  • Gene-age interactions
  • Genetics
  • Hypertension
  • Linkage
  • QTL effect

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Shi, G., Gu, C. C., Kraja, A. T., Arnett, D. K., Myers, R. H., Pankow, J. S., ... Rao, D. C. (2009). Genetic effect on blood pressure is modulated by age the hypertension genetic epidemiology network study. Hypertension, 53(1), 35-41. https://doi.org/10.1161/HYPERTENSIONAHA.108.120071

Genetic effect on blood pressure is modulated by age the hypertension genetic epidemiology network study. / Shi, Gang; Gu, Chi C.; Kraja, Aldi T.; Arnett, Donna K.; Myers, Richard H.; Pankow, James S.; Hunt, Steven; Rao, Dabeeru C.

In: Hypertension, Vol. 53, No. 1, 01.2009, p. 35-41.

Research output: Contribution to journalArticle

Shi, Gang ; Gu, Chi C. ; Kraja, Aldi T. ; Arnett, Donna K. ; Myers, Richard H. ; Pankow, James S. ; Hunt, Steven ; Rao, Dabeeru C. / Genetic effect on blood pressure is modulated by age the hypertension genetic epidemiology network study. In: Hypertension. 2009 ; Vol. 53, No. 1. pp. 35-41.
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