GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS

E. Mornet; J. L. Serre; M. Farrall; J. Boue; B. Simon-Bouy; Xavier P. Estivill; R. Williamson; A. Boue

doi:10.1016/S0140-6736(88)91180-4

GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS

E. Mornet, J. L. Serre, M. Farrall, J. Boue, B. Simon-Bouy, Xavier P. Estivill, R. Williamson, A. Boue

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Abstract

41 families with cystic fibrosis, (CF) were tested for restriction fragment length polymorphisms (RFLPs) detected by four DNA probes all of which are tightly linked to the CF gene. 17 of the families had an affected child with, and 24 had one without, meconium ileus. In all cases, CF segregates with these gene probes; however, those with and those without meconium ileus differed in haplotype for CF chromosomes with respect to pJ3.11, which suggests that because of multiallelism (different mutations of the same locus) some CF patients present with meconium ileus and others do not.

Original language	English
Pages (from-to)	376-378
Number of pages	3
Journal	The Lancet
Volume	331
Issue number	8582
DOIs	https://doi.org/10.1016/S0140-6736(88)91180-4
Publication status	Published - 20 Feb 1988
Externally published	Yes

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ASJC Scopus subject areas

Medicine(all)

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Mornet, E., Serre, J. L., Farrall, M., Boue, J., Simon-Bouy, B., Estivill, X. P., Williamson, R., & Boue, A. (1988). GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS. The Lancet, 331(8582), 376-378. https://doi.org/10.1016/S0140-6736(88)91180-4

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AU - Boue, J.

AU - Simon-Bouy, B.

AU - Estivill, Xavier P.

AU - Williamson, R.

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10.1016/S0140-6736(88)91180-4