GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS

E. Mornet, J. L. Serre, M. Farrall, J. Boue, B. Simon-Bouy, Xavier P. Estivill, R. Williamson, A. Boue

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

41 families with cystic fibrosis, (CF) were tested for restriction fragment length polymorphisms (RFLPs) detected by four DNA probes all of which are tightly linked to the CF gene. 17 of the families had an affected child with, and 24 had one without, meconium ileus. In all cases, CF segregates with these gene probes; however, those with and those without meconium ileus differed in haplotype for CF chromosomes with respect to pJ3.11, which suggests that because of multiallelism (different mutations of the same locus) some CF patients present with meconium ileus and others do not.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalThe Lancet
Volume331
Issue number8582
DOIs
Publication statusPublished - 20 Feb 1988
Externally publishedYes

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Meconium
Ileus
Cystic Fibrosis
DNA Probes
Restriction Fragment Length Polymorphisms
Haplotypes
Genes
Chromosomes
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mornet, E., Serre, J. L., Farrall, M., Boue, J., Simon-Bouy, B., Estivill, X. P., ... Boue, A. (1988). GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS. The Lancet, 331(8582), 376-378. https://doi.org/10.1016/S0140-6736(88)91180-4

GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS. / Mornet, E.; Serre, J. L.; Farrall, M.; Boue, J.; Simon-Bouy, B.; Estivill, Xavier P.; Williamson, R.; Boue, A.

In: The Lancet, Vol. 331, No. 8582, 20.02.1988, p. 376-378.

Research output: Contribution to journalArticle

Mornet, E, Serre, JL, Farrall, M, Boue, J, Simon-Bouy, B, Estivill, XP, Williamson, R & Boue, A 1988, 'GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS', The Lancet, vol. 331, no. 8582, pp. 376-378. https://doi.org/10.1016/S0140-6736(88)91180-4
Mornet, E. ; Serre, J. L. ; Farrall, M. ; Boue, J. ; Simon-Bouy, B. ; Estivill, Xavier P. ; Williamson, R. ; Boue, A. / GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS. In: The Lancet. 1988 ; Vol. 331, No. 8582. pp. 376-378.
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