Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs

Asem Alkhateeb, Firas Qarqaz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Generalized vitiligo is an autoimmune disorder characterized by patchy loss of pigmentation due to autoimmune destruction of melanocytes in the involved areas. Vitiligo is a polygenic, multifactorial disorder involving multiple genes and unknown environmental triggers. Recently, genetic variation in NALP1 (also called NLRP1), encoding a key regulator of the innate immune response, has been associated with generalized vitiligo in Caucasians of northern European origin. Here, we have investigated whether NALP1 is also associated with generalized vitiligo in Jordanian Arab patients. We genotyped 8 NALP1 singlenucleotide polymorphisms (SNPs) in 26 generalized vitiligo patients and 61 matched controls unaffected by vitiligo or any other autoimmune disorder. We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association. These results indicate that NALP1 is associated with susceptibility to generalized vitiligo in Arabs, as in Caucasians. Whether the casual variants are the same of not is yet to be identified by functional analysis.

Original languageEnglish
Pages (from-to)631-634
Number of pages4
JournalArchives of Dermatological Research
Volume302
Issue number8
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Fingerprint

Vitiligo
Melanocytes
Pigmentation
Innate Immunity
Genetic Promoter Regions

Keywords

  • Association
  • NALP1
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology

Cite this

Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs. / Alkhateeb, Asem; Qarqaz, Firas.

In: Archives of Dermatological Research, Vol. 302, No. 8, 10.2010, p. 631-634.

Research output: Contribution to journalArticle

Alkhateeb, Asem ; Qarqaz, Firas. / Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs. In: Archives of Dermatological Research. 2010 ; Vol. 302, No. 8. pp. 631-634.
@article{7620b440db8b4db4906219b456480587,
title = "Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs",
abstract = "Generalized vitiligo is an autoimmune disorder characterized by patchy loss of pigmentation due to autoimmune destruction of melanocytes in the involved areas. Vitiligo is a polygenic, multifactorial disorder involving multiple genes and unknown environmental triggers. Recently, genetic variation in NALP1 (also called NLRP1), encoding a key regulator of the innate immune response, has been associated with generalized vitiligo in Caucasians of northern European origin. Here, we have investigated whether NALP1 is also associated with generalized vitiligo in Jordanian Arab patients. We genotyped 8 NALP1 singlenucleotide polymorphisms (SNPs) in 26 generalized vitiligo patients and 61 matched controls unaffected by vitiligo or any other autoimmune disorder. We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association. These results indicate that NALP1 is associated with susceptibility to generalized vitiligo in Arabs, as in Caucasians. Whether the casual variants are the same of not is yet to be identified by functional analysis.",
keywords = "Association, NALP1, Vitiligo",
author = "Asem Alkhateeb and Firas Qarqaz",
year = "2010",
month = "10",
doi = "10.1007/s00403-010-1064-1",
language = "English",
volume = "302",
pages = "631--634",
journal = "Archives of Dermatological Research",
issn = "0340-3696",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs

AU - Alkhateeb, Asem

AU - Qarqaz, Firas

PY - 2010/10

Y1 - 2010/10

N2 - Generalized vitiligo is an autoimmune disorder characterized by patchy loss of pigmentation due to autoimmune destruction of melanocytes in the involved areas. Vitiligo is a polygenic, multifactorial disorder involving multiple genes and unknown environmental triggers. Recently, genetic variation in NALP1 (also called NLRP1), encoding a key regulator of the innate immune response, has been associated with generalized vitiligo in Caucasians of northern European origin. Here, we have investigated whether NALP1 is also associated with generalized vitiligo in Jordanian Arab patients. We genotyped 8 NALP1 singlenucleotide polymorphisms (SNPs) in 26 generalized vitiligo patients and 61 matched controls unaffected by vitiligo or any other autoimmune disorder. We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association. These results indicate that NALP1 is associated with susceptibility to generalized vitiligo in Arabs, as in Caucasians. Whether the casual variants are the same of not is yet to be identified by functional analysis.

AB - Generalized vitiligo is an autoimmune disorder characterized by patchy loss of pigmentation due to autoimmune destruction of melanocytes in the involved areas. Vitiligo is a polygenic, multifactorial disorder involving multiple genes and unknown environmental triggers. Recently, genetic variation in NALP1 (also called NLRP1), encoding a key regulator of the innate immune response, has been associated with generalized vitiligo in Caucasians of northern European origin. Here, we have investigated whether NALP1 is also associated with generalized vitiligo in Jordanian Arab patients. We genotyped 8 NALP1 singlenucleotide polymorphisms (SNPs) in 26 generalized vitiligo patients and 61 matched controls unaffected by vitiligo or any other autoimmune disorder. We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association. These results indicate that NALP1 is associated with susceptibility to generalized vitiligo in Arabs, as in Caucasians. Whether the casual variants are the same of not is yet to be identified by functional analysis.

KW - Association

KW - NALP1

KW - Vitiligo

UR - http://www.scopus.com/inward/record.url?scp=77958088176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958088176&partnerID=8YFLogxK

U2 - 10.1007/s00403-010-1064-1

DO - 10.1007/s00403-010-1064-1

M3 - Article

C2 - 20574744

AN - SCOPUS:77958088176

VL - 302

SP - 631

EP - 634

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

SN - 0340-3696

IS - 8

ER -