Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan

Manabu Wada, Makoto Daimon, Mitsuru Emi, Hiroshi Iijima, Hidenori Sato, Satoru Koyano, Katsushi Tajima, Toru Kawanami, Keiji Kurita, Steven Hunt, Paul N. Hopkins, Isao Kubota, Sumio Kawata, Takeo Kato

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Abstract

Aim: Moderate alcohol consumption appears to confer some protection against coronary heart disease, which is related to an increase in high-density lipoprotein cholesterol (HDL-C). The genotype of aldehyde dehydrogenase 2 (ALDH2) is closely related to alcohol metabolism but a relationship between ALDH2 genotypes and HDL-C levels has not been proven. We undertook a large-scale correlation study between HDL-C levels and ALDH2 genotype among Japanese non-drinkers to investigate the possibility that HDL-C levels could be associated with ALDH2 genotype. Methods: We examined a population-based sample of Japanese subjects who do not consume alcohol (n=1,736) to investigate the relationship between ALDH2 genotypes and lipid or lipoprotein concentrations in serum. We also investigated whether an association between ALDH2 genotype and HDL-C levels might be found in another Japanese sample. Results: In an independent population of non-drinkers from a different geographical region of Japan, HDL-C levels were associated with the same ALDH2 genotypes. Conclusions: The results of the present study suggested that genetic variation in the ALDH2 gene can influence HDL-C levels, independent of alcohol consumption.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalJournal of Atherosclerosis and Thrombosis
Volume15
Issue number4
Publication statusPublished - 2008
Externally publishedYes

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Keywords

  • Aldehyde dehydrogenase 2
  • Association study
  • High-density lipoprotein
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Wada, M., Daimon, M., Emi, M., Iijima, H., Sato, H., Koyano, S., Tajima, K., Kawanami, T., Kurita, K., Hunt, S., Hopkins, P. N., Kubota, I., Kawata, S., & Kato, T. (2008). Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan. Journal of Atherosclerosis and Thrombosis, 15(4), 179-184.