Genetic architecture of complex traits predisposing to nephropathy

Hypertension

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Blood pressure and hypertension have significant genetic underpinnings that may be age-dependent. The age-dependency, significant contributions from environmental factors such as diet and exercise, and inherent moment-to-moment variability complicate the identification of the genes contributing to the development of hypertension. Although genetic abnormalities may have moderate effects, the physiologic pathways involving these genes have redundant compensating mechanisms to bring the system back into equilibrium. This has the effect of reducing or completely masking the initial genetic defects, one of the hypothesized reasons for the small genetic effects found by the recent genome-wide association studies. This review article discusses the concept of initiators versus compensators in the context of finding genes related to hypertension development. A brief review is provided of some key genes found to be associated with hypertension, including the genes identified from the nine genome-wide association studies published to date.

Original languageEnglish
Pages (from-to)150-163
Number of pages14
JournalSeminars in Nephrology
Volume30
Issue number2
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

Fingerprint

Hypertension
Genes
Genome-Wide Association Study
Diet
Blood Pressure

Keywords

  • Blood pressure
  • Genetics
  • Genome-wide association
  • Heritability
  • Hypertension
  • Review
  • Salt sensitivity

ASJC Scopus subject areas

  • Nephrology

Cite this

Genetic architecture of complex traits predisposing to nephropathy : Hypertension. / Hunt, Steven.

In: Seminars in Nephrology, Vol. 30, No. 2, 03.2010, p. 150-163.

Research output: Contribution to journalArticle

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