Generation of specific secondary cytotoxic T cells by treatment of long-term primary MLC cells with sodium periodate

Manikkam Suthanthiran, K. H. Stenzel, A. L. Rubin, A. Novogrodsky

Research output: Contribution to journalArticle

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Abstract

The authors report that human memory cells, generated in a longterm primary mixed lymphocyte culture (MLC), cytolytically active T cells (CTL) when treated with sodium periodate (NaIO4), thus bypassing alloantigen requirements. In contrast, treatment of unprimed peripheral blood lymphocytes with NaIO4 fails to induce the generation of CTL, despite the blastogenesis induced by such treatment.

Original languageEnglish
Pages (from-to)1990-1991
Number of pages2
JournalTransplantation Proceedings
Volume11
Issue number4
Publication statusPublished - 1 Dec 1979
Externally publishedYes

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Cell Culture Techniques
Lymphocytes
T-Lymphocytes
Isoantigens
Lymphocyte Activation
metaperiodate

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Generation of specific secondary cytotoxic T cells by treatment of long-term primary MLC cells with sodium periodate. / Suthanthiran, Manikkam; Stenzel, K. H.; Rubin, A. L.; Novogrodsky, A.

In: Transplantation Proceedings, Vol. 11, No. 4, 01.12.1979, p. 1990-1991.

Research output: Contribution to journalArticle

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