Generation of histo-anatomically representative models of the individual heart: Tools and application

Gernot Plank, Rebecca A.B. Burton, Patrick Hales, Martin Bishop, Tahir Mansoori, Miguel O. Bernabeu, Alan Garny, Anton J. Prassl, Christian Bollensdorff, Fleur Mason, Fahd Mahmood, Blanca Rodriguez, Vicente Grau, Jürgen E. Schneider, David Gavaghan, Peter Kohl

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    123 Citations (Scopus)

    Abstract

    This paper presents methods to build histo-anatomically detailed individualized cardiac models. The models are based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and are used to investigate individualized cardiac function. The current state of the art is reviewed, and its limitations are discussed. We assess the challenges associated with the generation of histo-anatomically representative individualized in silico models of the heart. The entire processing pipeline including image acquisition, image processing, mesh generation, model set-up and execution of computer simulations, and the underlying methods are described. The multifaceted challenges associated with these goals are highlighted, suitable solutions are proposed, and an important application of developed highresolution structure-function models in elucidating the effect of individual structural heterogeneity upon wavefront dynamics is demonstrated.

    Original languageEnglish
    Pages (from-to)2257-2292
    Number of pages36
    JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
    Volume367
    Issue number1896
    DOIs
    Publication statusPublished - 13 Jun 2009

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    Keywords

    • Bidomain
    • Cardiac electrical activity
    • In silico heart model
    • Individualized medicine
    • Multiscale modelling
    • Parallel computing

    ASJC Scopus subject areas

    • Mathematics(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    Plank, G., Burton, R. A. B., Hales, P., Bishop, M., Mansoori, T., Bernabeu, M. O., Garny, A., Prassl, A. J., Bollensdorff, C., Mason, F., Mahmood, F., Rodriguez, B., Grau, V., Schneider, J. E., Gavaghan, D., & Kohl, P. (2009). Generation of histo-anatomically representative models of the individual heart: Tools and application. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 367(1896), 2257-2292. https://doi.org/10.1098/rsta.2009.0056