Generation of histo-anatomically representative models of the individual heart: Tools and application

Gernot Plank, Rebecca A B Burton, Patrick Hales, Martin Bishop, Tahir Mansoori, Miguel O. Bernabeu, Alan Garny, Anton J. Prassl, Christian Bollensdorff, Fleur Mason, Fahd Mahmood, Blanca Rodriguez, Vicente Grau, Jürgen E. Schneider, David Gavaghan, Peter Kohl

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

This paper presents methods to build histo-anatomically detailed individualized cardiac models. The models are based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and are used to investigate individualized cardiac function. The current state of the art is reviewed, and its limitations are discussed. We assess the challenges associated with the generation of histo-anatomically representative individualized in silico models of the heart. The entire processing pipeline including image acquisition, image processing, mesh generation, model set-up and execution of computer simulations, and the underlying methods are described. The multifaceted challenges associated with these goals are highlighted, suitable solutions are proposed, and an important application of developed highresolution structure-function models in elucidating the effect of individual structural heterogeneity upon wavefront dynamics is demonstrated.

Original languageEnglish
Pages (from-to)2257-2292
Number of pages36
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume367
Issue number1896
DOIs
Publication statusPublished - 13 Jun 2009
Externally publishedYes

Fingerprint

Computer Simulation
Magnetic Resonance Spectroscopy
Cardiac
Mesh generation
Magnetic Resonance Image
Model
Image Acquisition
Image acquisition
Mesh Generation
Structure-function
Magnetic resonance
Wavefronts
Wave Front
Tensors
magnetic resonance
image processing
Image Processing
acquisition
Image processing
High Resolution

Keywords

  • Bidomain
  • Cardiac electrical activity
  • In silico heart model
  • Individualized medicine
  • Multiscale modelling
  • Parallel computing

ASJC Scopus subject areas

  • Mathematics(all)
  • Physics and Astronomy(all)
  • Engineering(all)

Cite this

Generation of histo-anatomically representative models of the individual heart : Tools and application. / Plank, Gernot; Burton, Rebecca A B; Hales, Patrick; Bishop, Martin; Mansoori, Tahir; Bernabeu, Miguel O.; Garny, Alan; Prassl, Anton J.; Bollensdorff, Christian; Mason, Fleur; Mahmood, Fahd; Rodriguez, Blanca; Grau, Vicente; Schneider, Jürgen E.; Gavaghan, David; Kohl, Peter.

In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 367, No. 1896, 13.06.2009, p. 2257-2292.

Research output: Contribution to journalArticle

Plank, G, Burton, RAB, Hales, P, Bishop, M, Mansoori, T, Bernabeu, MO, Garny, A, Prassl, AJ, Bollensdorff, C, Mason, F, Mahmood, F, Rodriguez, B, Grau, V, Schneider, JE, Gavaghan, D & Kohl, P 2009, 'Generation of histo-anatomically representative models of the individual heart: Tools and application', Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 367, no. 1896, pp. 2257-2292. https://doi.org/10.1098/rsta.2009.0056
Plank, Gernot ; Burton, Rebecca A B ; Hales, Patrick ; Bishop, Martin ; Mansoori, Tahir ; Bernabeu, Miguel O. ; Garny, Alan ; Prassl, Anton J. ; Bollensdorff, Christian ; Mason, Fleur ; Mahmood, Fahd ; Rodriguez, Blanca ; Grau, Vicente ; Schneider, Jürgen E. ; Gavaghan, David ; Kohl, Peter. / Generation of histo-anatomically representative models of the individual heart : Tools and application. In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2009 ; Vol. 367, No. 1896. pp. 2257-2292.
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