Gender-based analysis of cortical thickness and structural connectivity in Parkinson’s disease

Santosh K. Yadav, Nagarajan Kathiresan, Suyash Mohan, Georgia Vasileiou, Anup Singh, Deepak Kaura, Elias R. Melhem, Rakesh K. Gupta, Ena Wang, Francesco M. Marincola, Arijitt Borthakur, Mohammad Haris

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Parkinson’s disease (PD) is a progressive neurological disorder and appears to have gender-specific symptoms. Studies have observed a higher frequency for development of PD in male than in female. In the current study, we evaluated the gender-based changes in cortical thickness and structural connectivity in PD patients. With informed consent, 64 PD (43 males and 21 females) patients, and 46 (12 males and 34 females) age-matched controls underwent clinical assessment including Mini-Mental State Examination (MMSE) and magnetic resonance imaging on a 1.5 Tesla clinical MR scanner. Whole brain high-resolution T1-weighted images were acquired from all subjects and used to measure cortical thickness and structural network connectivity. No significant difference in MMSE score was observed between male and female both in control and PD subjects. Male PD patients showed significantly reduced cortical thickness in multiple brain regions including frontal, parietal, temporal, and occipital lobes as compared with those in female PD patients. The graph theory-based network analysis depicted lower connection strengths, lower clustering coefficients, and altered network hubs in PD male than in PD female. Male-specific cortical thickness changes and altered connectivity in PD patients may derive from behavioral, physiological, environmental, and genetical differences between male and female, and may have significant implications in diagnosing and treating PD among genders.

Original languageEnglish
Pages (from-to)2308-2318
Number of pages11
JournalJournal of Neurology
Issue number11
Publication statusPublished - 1 Nov 2016



  • Brain
  • Cortical thickness
  • Magnetic resonance imaging
  • Parkinson’s disease
  • Structural network connectivity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Yadav, S. K., Kathiresan, N., Mohan, S., Vasileiou, G., Singh, A., Kaura, D., Melhem, E. R., Gupta, R. K., Wang, E., Marincola, F. M., Borthakur, A., & Haris, M. (2016). Gender-based analysis of cortical thickness and structural connectivity in Parkinson’s disease. Journal of Neurology, 263(11), 2308-2318.