Gastrointestinal behçet's disease

A review

Wasseem Skef, Matthew J. Hamilton, Thurayya Arayssi

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. Prevalence of BD is highest in countries along the ancient silk road from the Mediterranean basin to East Asia. By comparison, the prevalence in North American and Northern European countries is low. Gastrointestinal manifestations of Behçet's disease are of particular importance as they are associated with significant morbidity and mortality. Although ileocecal involvement is most commonly described, BD may involve any segment of the intestinal tract as well as the various organs within the gastrointestinal system. Diagnosis is based on clinical criteria - there are no pathognomonic laboratory tests. Methods for monitoring disease activity on therapy are available but imperfect. Evidence-based treatment strategies are lacking. Different classes of medications have been successfully used for the treatment of intestinal BD which include 5-aminosalicylic acid, corticosteroids, immunomodulators, and anti-tumor necrosis factor alpha monoclonal antibody therapy. Like inflammatory bowel disease, surgery is reserved for those who are resistant to medical therapy. A subset of patients have a poor disease course. Accurate methods to detect these patients and the optimal strategy for their treatment are not known at this time.

Original languageEnglish
Pages (from-to)3801-3812
Number of pages12
JournalWorld Journal of Gastroenterology
Volume21
Issue number13
DOIs
Publication statusPublished - 7 Apr 2015

Fingerprint

Gastrointestinal Diseases
Therapeutics
Aphthous Stomatitis
Mesalamine
Systemic Vasculitis
Intestinal Diseases
Silk
Far East
Eye Diseases
Immunologic Factors
Inflammatory Bowel Diseases
Adrenal Cortex Hormones
Tumor Necrosis Factor-alpha
Monoclonal Antibodies
Morbidity
Skin
Mortality

Keywords

  • Behçet syndrome
  • Behçet's disease
  • Inflammatory bowel disease
  • Lower gastrointestinal tract
  • Ulcer
  • Upper gastrointestinal tract

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastrointestinal behçet's disease : A review. / Skef, Wasseem; Hamilton, Matthew J.; Arayssi, Thurayya.

In: World Journal of Gastroenterology, Vol. 21, No. 13, 07.04.2015, p. 3801-3812.

Research output: Contribution to journalReview article

Skef, Wasseem ; Hamilton, Matthew J. ; Arayssi, Thurayya. / Gastrointestinal behçet's disease : A review. In: World Journal of Gastroenterology. 2015 ; Vol. 21, No. 13. pp. 3801-3812.
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