Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers

Shigeru Kotake, H. Ralph Schumacher, Thurayya Arayssi, Herve C. Gérard, Patrick J. Branigan, Alan P. Hudson, Cheryl H. Yarboro, John H. Klippel, Ronald L. Wilder

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Abstract

Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-γ) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN- γ and additional cytokine genes in patients who had recent-onset Chlamydia- associated arthritis (Chl-AA). IL-10 and IFN-γ mRNA were relatively abundant in recent-onset Chl-AA.

Original languageEnglish
Pages (from-to)2682-2686
Number of pages5
JournalInfection and Immunity
Volume67
Issue number5
Publication statusPublished - May 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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