Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with met and pJ3.11

M. Farrall, E. Watson, G. Bates, G. Bell, J. Bell, K. A. Davies, Xavier P. Estivill, H. Kruyer, H. Y. Law, N. Lench

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Abstract

The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2-1-3.1. We report further linkage data with two polymorphic markers at the met oncogene locus, pmetH and pmetD, which supports the tight linkage found by White et al. between CF and met. One family shows evidence for meiotic recombination between CF and met. Analysis of haplotypes in CF pedigrees collected for linkage studies combined with data from single affected families requesting prenatal diagnosis (Farrall et al., Lancet i:1402-1404, 1986) shows CF and met to be in linkage equilibrium in our population shile pJ3.11-CF haplotypes show a deviation from the equilibrium frequencies.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalAmerican Journal of Human Genetics
Volume39
Issue number6
Publication statusPublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Farrall, M., Watson, E., Bates, G., Bell, G., Bell, J., Davies, K. A., Estivill, X. P., Kruyer, H., Law, H. Y., & Lench, N. (1986). Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with met and pJ3.11. American Journal of Human Genetics, 39(6), 713-719.