Further Analysis of Interpolation Effects in Mutual Information-Based Image Registration

Jim Ji, Hao Pan, Zhi Pei Liang

Research output: Contribution to journalArticle

41 Citations (Scopus)


This paper presents an analysis of the mutual information (MI) metric in rigid-body registration of two digital images, in particular, local fluctuations of the MI value due to interpolation. In contrast to existing work in this area, this paper starts with two hypothetical continuous images, based on which both sampling and interpolation effects are analyzed. This analysis indicates that an "ideal" interpolator may not be able to completely suppress the undesirable local minima of the MI metric if the sampling effect is not negligible. Several preprocessing methods are discussed for reducing the interpolation effects.

Original languageEnglish
Pages (from-to)1131-1140
Number of pages10
JournalIEEE Transactions on Medical Imaging
Issue number9
Publication statusPublished - Sep 2003
Externally publishedYes



  • Image registration
  • Interpolation effect
  • Mutual information
  • Sampling effect

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

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