Functional vascular endothelial growth factor - 2578 C/A polymorphism in relation to nasopharyngeal carcinoma risk and tumor progression

Hela Ben Nasr, Karim Chahed, Noureddine Bouaouina, Lotfi Chouchane

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and a potent regulator of angiogenesis and inflammatory processes in nasopharyngeal carcinomas. In the current report, we designed a case-controlled study to evaluate whether a genetically predetermined variation in the VEGF expression may affect susceptibility and prognosis. Methods: A PCR and restriction fragment length polymorphism analysis was used to determine the variation of the - 2578 C/A promoter region in a Tunisian population of patients with nasopharyngeal carcinomas (NPC) and in healthy control subjects. Results: A significantly risk of NPC was observed for carriers of VEGF - 2578 C allele (OR = 1.4; P = 0.03). Regarding prognostic indicators, a significant association was found between - 2578 C allele carriers and the aggressive forms of NPC as defined by large tumor size (OR = 2.29; P = 0.0002) and advanced tumor stages (OR = 1.97; P = 0.02). Moreover, an association was ascertained between the VEGF polymorphism and gender. Conclusions: This is the first report on the studies of functional VEGF polymorphisms in NPC and our preliminary data suggest that this genetic variant may play a role in mediating susceptibility to NPC, as well as, in neoplastic progression, supporting our hypothesis for VEGF involvement in NPC etiology.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalClinica Chimica Acta
Volume395
Issue number1-2
DOIs
Publication statusPublished - 1 Sep 2008

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Keywords

  • Nasopharyngeal carcinoma
  • Polymorphism
  • Prognosis
  • Susceptibility
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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