Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

Eynav Klechevsky, Rimpei Morita, Maochang Liu, Yanying Cao, Sebastien Coquery, Lu Ann Thompson-Snipes, Francine Briere, Damien J. Chaussabel, Gerard Zurawski, A. Karolina Palucka, Yoram Reiter, Jacques Banchereau, Hideki Ueno

Research output: Contribution to journalArticle

403 Citations (Scopus)

Abstract

Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

Original languageEnglish
Pages (from-to)497-510
Number of pages14
JournalImmunity
Volume29
Issue number3
DOIs
Publication statusPublished - 19 Sep 2008
Externally publishedYes

Fingerprint

Langerhans Cells
Dendritic Cells
Th2 Cells
Skin
Myeloid Cells
Dermis
Humoral Immunity
Plasma Cells
Cellular Immunity
B-Lymphocytes
Cytokines
Population

Keywords

  • CELLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L. A., ... Ueno, H. (2008). Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. Immunity, 29(3), 497-510. https://doi.org/10.1016/j.immuni.2008.07.013

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. / Klechevsky, Eynav; Morita, Rimpei; Liu, Maochang; Cao, Yanying; Coquery, Sebastien; Thompson-Snipes, Lu Ann; Briere, Francine; Chaussabel, Damien J.; Zurawski, Gerard; Palucka, A. Karolina; Reiter, Yoram; Banchereau, Jacques; Ueno, Hideki.

In: Immunity, Vol. 29, No. 3, 19.09.2008, p. 497-510.

Research output: Contribution to journalArticle

Klechevsky, E, Morita, R, Liu, M, Cao, Y, Coquery, S, Thompson-Snipes, LA, Briere, F, Chaussabel, DJ, Zurawski, G, Palucka, AK, Reiter, Y, Banchereau, J & Ueno, H 2008, 'Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells', Immunity, vol. 29, no. 3, pp. 497-510. https://doi.org/10.1016/j.immuni.2008.07.013
Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes LA et al. Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. Immunity. 2008 Sep 19;29(3):497-510. https://doi.org/10.1016/j.immuni.2008.07.013
Klechevsky, Eynav ; Morita, Rimpei ; Liu, Maochang ; Cao, Yanying ; Coquery, Sebastien ; Thompson-Snipes, Lu Ann ; Briere, Francine ; Chaussabel, Damien J. ; Zurawski, Gerard ; Palucka, A. Karolina ; Reiter, Yoram ; Banchereau, Jacques ; Ueno, Hideki. / Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. In: Immunity. 2008 ; Vol. 29, No. 3. pp. 497-510.
@article{18f40c65dda943129233f40710547e88,
title = "Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells",
abstract = "Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.",
keywords = "CELLIMMUNO",
author = "Eynav Klechevsky and Rimpei Morita and Maochang Liu and Yanying Cao and Sebastien Coquery and Thompson-Snipes, {Lu Ann} and Francine Briere and Chaussabel, {Damien J.} and Gerard Zurawski and Palucka, {A. Karolina} and Yoram Reiter and Jacques Banchereau and Hideki Ueno",
year = "2008",
month = "9",
day = "19",
doi = "10.1016/j.immuni.2008.07.013",
language = "English",
volume = "29",
pages = "497--510",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

AU - Klechevsky, Eynav

AU - Morita, Rimpei

AU - Liu, Maochang

AU - Cao, Yanying

AU - Coquery, Sebastien

AU - Thompson-Snipes, Lu Ann

AU - Briere, Francine

AU - Chaussabel, Damien J.

AU - Zurawski, Gerard

AU - Palucka, A. Karolina

AU - Reiter, Yoram

AU - Banchereau, Jacques

AU - Ueno, Hideki

PY - 2008/9/19

Y1 - 2008/9/19

N2 - Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

AB - Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

KW - CELLIMMUNO

UR - http://www.scopus.com/inward/record.url?scp=51349093240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349093240&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2008.07.013

DO - 10.1016/j.immuni.2008.07.013

M3 - Article

VL - 29

SP - 497

EP - 510

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 3

ER -