Functional In Vivo Imaging of Tumors

Mohammad Haris, Sabah Nisar, Sheema Hashem, Ajaz A. Bhat, Santosh Yadav, Muralitharan Shanmugakonar, Hamda Al-Naemi, Puneet Bagga, Shahab Uddin, Ravinder Reddy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the in vivo analysis of the mechanisms such as gene expression, signal transduction, biochemical reactions, regulatory pathways, cell trafficking, and drug action underlying cancer noninvasively. The main focus of imaging in cancer is the development of new contrast methods/molecular probes for the early diagnosis and the precise evaluation of therapy response. In clinical setup, imaging modalities facilitate screening, prediction, staging, biopsy and therapy guidance, therapy response, therapy planning, and prognosis of cancer. In this book chapter, we review different established and emerging in vivo imaging modalities and their applications in monitoring functional, molecular, and metabolic changes in cancer.

Original languageEnglish
Title of host publicationCancer Treatment and Research
PublisherSpringer
Pages3-50
Number of pages48
DOIs
Publication statusPublished - 1 Jan 2020

Publication series

NameCancer Treatment and Research
Volume180
ISSN (Print)0927-3042
ISSN (Electronic)2509-8497

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Keywords

  • Biomedical imaging
  • Chemical exchange saturation transfer
  • Hyperpolarization
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Optical imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Haris, M., Nisar, S., Hashem, S., Bhat, A. A., Yadav, S., Shanmugakonar, M., Al-Naemi, H., Bagga, P., Uddin, S., & Reddy, R. (2020). Functional In Vivo Imaging of Tumors. In Cancer Treatment and Research (pp. 3-50). (Cancer Treatment and Research; Vol. 180). Springer. https://doi.org/10.1007/978-3-030-38862-1_1