Fulminant hepatic failure and the potential role of liver dialysis

M. Akdogan, M. Aladag, S. Rashwan, S. Shrago, E. Warner, A. Sebastian, H. Wright, B. Nour, Ahmet Gurakar

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Fulminant hepatic failure (FHF) carries a high mortality. We aimed to review the prognostic factors and explore the potential role of Liver Dialysis (LD). Fifty-two patients were reviewed. The etiologies were acetaminophen toxicity (33%), viral hepatitis (18%), autoimmune (10%), idiosyncratic drug reactions (8%), others (6%) and undetermined (25%). Patients with acetaminophen had a significantly higher survival compared to the non-acetaminophen group (p=0.04). Patients with grade 3 encephalopathy had a mortality of 68%, among 5 patients with grade IV encephalopathy, 2 survived and both had had treatment with LD. Chi-square with Fisher's exact test was used for statistical analysis. Our study confirmed that the diagnosis of non-acetaminophen induced FHF and reduced initial serum factor V level are associated with fatal outcome. Timely OLT significantly improved the survival. The role of LD in hepatic regeneration or as a bridge to OLT needs to be further studied with prospective control trials.

Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalInternational Journal of Artificial Organs
Volume27
Issue number11
Publication statusPublished - 1 Dec 2004

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Keywords

  • Acetaminophen toxicity
  • Fulminant hepatic failure
  • Liver dialysis
  • Total plasma exchange

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Akdogan, M., Aladag, M., Rashwan, S., Shrago, S., Warner, E., Sebastian, A., Wright, H., Nour, B., & Gurakar, A. (2004). Fulminant hepatic failure and the potential role of liver dialysis. International Journal of Artificial Organs, 27(11), 956-961.