Fulminant hepatic failure and the potential role of liver dialysis

M. Akdogan, M. Aladag, S. Rashwan, S. Shrago, E. Warner, A. Sebastian, H. Wright, Bakr Nour, Ahmet Gurakar

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Fulminant hepatic failure (FHF) carries a high mortality. We aimed to review the prognostic factors and explore the potential role of Liver Dialysis (LD). Fifty-two patients were reviewed. The etiologies were acetaminophen toxicity (33%), viral hepatitis (18%), autoimmune (10%), idiosyncratic drug reactions (8%), others (6%) and undetermined (25%). Patients with acetaminophen had a significantly higher survival compared to the non-acetaminophen group (p=0.04). Patients with grade 3 encephalopathy had a mortality of 68%, among 5 patients with grade IV encephalopathy, 2 survived and both had had treatment with LD. Chi-square with Fisher's exact test was used for statistical analysis. Our study confirmed that the diagnosis of non-acetaminophen induced FHF and reduced initial serum factor V level are associated with fatal outcome. Timely OLT significantly improved the survival. The role of LD in hepatic regeneration or as a bridge to OLT needs to be further studied with prospective control trials.

Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalInternational Journal of Artificial Organs
Volume27
Issue number11
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Dialysis
Acute Liver Failure
Liver
Acetaminophen
Brain Diseases
Factor V
Autoimmune Hepatitis
Fatal Outcome
Survival
Toxicity
Mortality
Statistical methods
Regeneration
Pharmaceutical Preparations
Serum
Therapeutics

Keywords

  • Acetaminophen toxicity
  • Fulminant hepatic failure
  • Liver dialysis
  • Total plasma exchange

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Akdogan, M., Aladag, M., Rashwan, S., Shrago, S., Warner, E., Sebastian, A., ... Gurakar, A. (2004). Fulminant hepatic failure and the potential role of liver dialysis. International Journal of Artificial Organs, 27(11), 956-961.

Fulminant hepatic failure and the potential role of liver dialysis. / Akdogan, M.; Aladag, M.; Rashwan, S.; Shrago, S.; Warner, E.; Sebastian, A.; Wright, H.; Nour, Bakr; Gurakar, Ahmet.

In: International Journal of Artificial Organs, Vol. 27, No. 11, 2004, p. 956-961.

Research output: Contribution to journalReview article

Akdogan, M, Aladag, M, Rashwan, S, Shrago, S, Warner, E, Sebastian, A, Wright, H, Nour, B & Gurakar, A 2004, 'Fulminant hepatic failure and the potential role of liver dialysis', International Journal of Artificial Organs, vol. 27, no. 11, pp. 956-961.
Akdogan M, Aladag M, Rashwan S, Shrago S, Warner E, Sebastian A et al. Fulminant hepatic failure and the potential role of liver dialysis. International Journal of Artificial Organs. 2004;27(11):956-961.
Akdogan, M. ; Aladag, M. ; Rashwan, S. ; Shrago, S. ; Warner, E. ; Sebastian, A. ; Wright, H. ; Nour, Bakr ; Gurakar, Ahmet. / Fulminant hepatic failure and the potential role of liver dialysis. In: International Journal of Artificial Organs. 2004 ; Vol. 27, No. 11. pp. 956-961.
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