From the delayed allergy reaction to the immunologic constant of rejection

Ena Wang, Francesco M. Marincola

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as immune-mediated, tissue-specific destruction (TSD) (Wang et al. 2008), comprises a broad range of -phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host vs. graft reactions. Like different hands can turn on or off a switch, distinct-mechanisms can trigger TSD, however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation (Mantovani et al. 2008).

Original languageEnglish
Title of host publicationImmunologic Signatures of Rejection
PublisherSpringer New York
Number of pages6
ISBN (Electronic)9781441972194
ISBN (Print)9781441972187
Publication statusPublished - 2011
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, E., & Marincola, F. M. (2011). From the delayed allergy reaction to the immunologic constant of rejection. In Immunologic Signatures of Rejection (pp. 3-8). Springer New York.