Forecasting the cytokine storm following systematic interleukin (IL)-2 administration

Monica C. Panelli, Richard White, Mareva Foster, Brian Martin, Ena Wang, Kina Smith, Francesco M. Marincola

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Abstract

Extensive clinical experience has shown that systemic interleukin (IL)-2 administration can induce complete or partial regression of renal cell cancer (RCC) metastases in 15 to 20 % of patients. Since IL-2 has no direct anti-cancer effects, it is believed that cancer regression is mediated either by a direct modulation of immune cell effector functions or through the mediation of soluble factors released as a result of IL-2 administration. We previously observed that transcriptional and protein changes induced by systemic IL-2 administration affect predominantly mononuclear phagocytes with little effect, particularly within the tumor microenvironment, on T cell activation, localization and proliferation. It further appeared that mononuclear phagocyte activation could be best explained by the indirect mediation of a secondary release of cytokines by IL-2 responsive cells either in the circulation or in peripheral tissues.

Original languageEnglish
Article number17
JournalJournal of translational medicine
Volume2
DOIs
Publication statusPublished - 2 Jun 2004

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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