Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

Marek Samec, Alena Liskova, Lenka Koklesova, Veronika Mestanova, Maria Franekova, Monika Kassayova, Bianka Bojkova, Sona Uramova, Pavol Zubor, Katarina Janikova, Jan Danko, Samson Mathews Samuel, Dietrich Büsselberg, Peter Kubatka

Research output: Contribution to journalReview article

Abstract

Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell's epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.

Original languageEnglish
JournalBiomolecules
Volume9
Issue number12
DOIs
Publication statusPublished - 5 Dec 2019

Fingerprint

Histone Code
Chemical modification
Phytochemicals
Post Translational Protein Processing
Histones
Chromatin
Colorectal Neoplasms
Prostatic Neoplasms
Breast Neoplasms
Neoplasms
Modulation
Acetylation
Methylation
Transcription
Aberrations
Oncogenes
Research
Gene expression
Antineoplastic Agents
Carcinogenesis

Keywords

  • breast cancer
  • colorectal cancer
  • epigenetics
  • histone
  • phytochemicals
  • posttranslational chemical modifications
  • prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer : An Implication of Phytochemicals as Defenders of Chromatin Equilibrium. / Samec, Marek; Liskova, Alena; Koklesova, Lenka; Mestanova, Veronika; Franekova, Maria; Kassayova, Monika; Bojkova, Bianka; Uramova, Sona; Zubor, Pavol; Janikova, Katarina; Danko, Jan; Samuel, Samson Mathews; Büsselberg, Dietrich; Kubatka, Peter.

In: Biomolecules, Vol. 9, No. 12, 05.12.2019.

Research output: Contribution to journalReview article

Samec, M, Liskova, A, Koklesova, L, Mestanova, V, Franekova, M, Kassayova, M, Bojkova, B, Uramova, S, Zubor, P, Janikova, K, Danko, J, Samuel, SM, Büsselberg, D & Kubatka, P 2019, 'Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium', Biomolecules, vol. 9, no. 12. https://doi.org/10.3390/biom9120829
Samec, Marek ; Liskova, Alena ; Koklesova, Lenka ; Mestanova, Veronika ; Franekova, Maria ; Kassayova, Monika ; Bojkova, Bianka ; Uramova, Sona ; Zubor, Pavol ; Janikova, Katarina ; Danko, Jan ; Samuel, Samson Mathews ; Büsselberg, Dietrich ; Kubatka, Peter. / Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer : An Implication of Phytochemicals as Defenders of Chromatin Equilibrium. In: Biomolecules. 2019 ; Vol. 9, No. 12.
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