Flavonoids in cancer and apoptosis

Mariam Abotaleb, Samson Mathews Samuel, Elizabeth Varghese, Sharon Varghese, Peter Kubatka, Alena Liskova, Dietrich Busselberg

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.

Original languageEnglish
Article number28
JournalCancers
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

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Keywords

  • Anti-cancer therapy
  • Apoptosis
  • Cancer
  • Flavonoids
  • Natural compounds
  • Phytochemicals

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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