Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

Raghad Khalid Al-Ishaq, Mariam Abotaleb, Peter Kubatka, Karol Kajo, Dietrich Busselberg

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming incidence rate and a huge burden on health care providers. DM is characterized by the elevation of blood glucose due either to a defect in insulin synthesis, secretion, binding to receptor, or an increase of insulin resistance. The internal and external factors such as obesity, urbanizations, and genetic mutations could increase the risk of developing DM. Flavonoids are phenolic compounds existing as secondary metabolites in fruits and vegetables as well as fungi. Their structure consists of 15 carbon skeletons and two aromatic rings (A and B) connected by three carbon chains. Flavonoids are furtherly classified into 6 subclasses: flavonols, flavones, flavanones, isoflavones, flavanols, and anthocyanidins. Naturally occurring flavonoids possess anti-diabetic effects. As in vitro and animal model's studies demonstrate, they have the ability to prevent diabetes and its complications. The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB. Flavonoids improve the pathogenesis of diabetes and its complications through the regulation of glucose metabolism, hepatic enzymes activities, and a lipid profile. Most studies illustrate a positive role of specific dietary flavonoids on diabetes, but the mechanisms of action and the side effects need more clarification. Overall, more research is needed to provide a better understanding of the mechanisms of diabetes treatment using flavonoids.

Original languageEnglish
JournalBiomolecules
Volume9
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Medical problems
Flavonoids
Blood Glucose
Diabetes Mellitus
Diabetes Complications
Carbon
Flavanones
Insulin
Flavones
Flavonols
Peroxisome Proliferator-Activated Receptors
Urbanization
AMP-Activated Protein Kinases
Isoflavones
Facilitative Glucose Transport Proteins
Anthocyanins
Liver
Vegetables
Enzyme activity
Enzymes

Keywords

  • anti-diabetic
  • diabetes mellitus
  • flavonoids
  • hyperglycemia
  • lipogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Flavonoids and Their Anti-Diabetic Effects : Cellular Mechanisms and Effects to Improve Blood Sugar Levels. / Al-Ishaq, Raghad Khalid; Abotaleb, Mariam; Kubatka, Peter; Kajo, Karol; Busselberg, Dietrich.

In: Biomolecules, Vol. 9, No. 9, 01.09.2019.

Research output: Contribution to journalReview article

Al-Ishaq, Raghad Khalid ; Abotaleb, Mariam ; Kubatka, Peter ; Kajo, Karol ; Busselberg, Dietrich. / Flavonoids and Their Anti-Diabetic Effects : Cellular Mechanisms and Effects to Improve Blood Sugar Levels. In: Biomolecules. 2019 ; Vol. 9, No. 9.
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