Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs

S. I. Rennard, J. Moss, J. Oberpriller, B. Hom, L. Stier, T. Ozaki, Ronald Crystal

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Abstract

To evaluate whether such prostaglandins can alter lung connective tissue secretion by lung fibroblasts, the ability of prostaglandins to modulate the secretion of collagen and fibronectin by HFL-1 cells was determined using an enzyme immunoassay for human type I collagen and for human fibronectin. PGE1 and PGE2 caused a 29 ± 6% reduction in type I collagen secretion but, in contrast, a 39 ± 7% increase in fibronectin secretion (p < 0.01, all comparisons to control). In contrast, PGF(2α), (a prostaglandin which frequently has effects opposite those of PGE1 and PGE2) had no effect on type I collagen secretion (99 ± 7% of control, p > 0.2) bu caused a 20 ± 3% reduction in fibronectin secretion (p < 0.05). Thus fibroblasts are capable of specific modulation of connective macromolecule secretion in response to progstaglandins. Both through the production of prostaglandins and as a target for these mediators, lung fibroblasts play an important role in the cellular response to lung inflammation.

Original languageEnglish
JournalChest
Volume83
Issue number5 Suppl.
Publication statusPublished - 7 Jul 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Rennard, S. I., Moss, J., Oberpriller, J., Hom, B., Stier, L., Ozaki, T., & Crystal, R. (1983). Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs. Chest, 83(5 Suppl.).