Familial Mediterranean fever in children: The expanded clinical profile

H. A. Majeed, M. Rawashdeh, H. El-Shanti, H. Qubain, N. Khuri-Bulos, H. M. Shahin

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The clinical picture of familial Mediterranean fever (FMF) has been appreciably expanded in the last 10 years. Over 8 years, we studied the expanded clinical profile of FMF in 476 children. Of these, 81% had abdominal pain, 41% chest pain, 42% arthritis, 12% severe myalgia, 12% skin manifestations, 4% scrotal swelling, 3% recurrent episodic fever, and one child (0.2%) developed recurrent hyperbilirubinaemia. Two (0.4%) children developed renal complications which were reversed by colchicine; however of 19 probands, 36 family members suffered from chronic renal failure. Our study indicates a familial predisposition to nephropathy in certain families with FMF. This study is the first to report the expanded clinical profile of FMF in a large group of Arab children, giving an opportunity to compare the findings with those in children with FMF in other ethnic groups, and to help in the study of genotype-phenotype correlation.

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalQJM - Monthly Journal of the Association of Physicians
Volume92
Issue number6
Publication statusPublished - Jun 1999
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Majeed, H. A., Rawashdeh, M., El-Shanti, H., Qubain, H., Khuri-Bulos, N., & Shahin, H. M. (1999). Familial Mediterranean fever in children: The expanded clinical profile. QJM - Monthly Journal of the Association of Physicians, 92(6), 309-318.