Familial Mediterranean fever in Arabs

Hatem El-Shanti, Hasan Abdel Majeed, Mohammed El-Khateeb

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    105 Citations (Scopus)


    Autoinflammatory diseases are a group of disorders characterised by seemingly unprovoked inflammation in the absence of high-titre autoantibodies or antigen-specific T cells, and include the hereditary periodic fever syndromes. Familial Mediterranean fever (FMF) is an archetypal autoinflammatory disorder, which is autosomal recessive and has a high prevalence in non-Ashkenazi Jews, Armenians, Turks, and Arabs. The classic clinical picture is recurrent acute short-lived febrile and painful attacks with variable periods of remission. In a subset of patients, the disorder is complicated by amyloidosis that leads to renal failure. The gene responsible for FMF - MEFV - has been identified and its role in inflammation is being assessed. There seems to be a distinctive clinical picture in Arab patients with FMF, and the range and distribution of MEFV mutations is different from that noted in other affected ethnic groups. Here, we discuss the clinical and molecular aspects of FMF in Arabs.

    Original languageEnglish
    Pages (from-to)1016-1024
    Number of pages9
    Issue number9515
    Publication statusPublished - 25 Mar 2006


    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    El-Shanti, H., Majeed, H. A., & El-Khateeb, M. (2006). Familial Mediterranean fever in Arabs. Lancet, 367(9515), 1016-1024. https://doi.org/10.1016/S0140-6736(06)68430-4