Familial Mediterranean fever in Arabs

Hatem El-Shanti, Hasan Abdel Majeed, Mohammed El-Khateeb

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Autoinflammatory diseases are a group of disorders characterised by seemingly unprovoked inflammation in the absence of high-titre autoantibodies or antigen-specific T cells, and include the hereditary periodic fever syndromes. Familial Mediterranean fever (FMF) is an archetypal autoinflammatory disorder, which is autosomal recessive and has a high prevalence in non-Ashkenazi Jews, Armenians, Turks, and Arabs. The classic clinical picture is recurrent acute short-lived febrile and painful attacks with variable periods of remission. In a subset of patients, the disorder is complicated by amyloidosis that leads to renal failure. The gene responsible for FMF - MEFV - has been identified and its role in inflammation is being assessed. There seems to be a distinctive clinical picture in Arab patients with FMF, and the range and distribution of MEFV mutations is different from that noted in other affected ethnic groups. Here, we discuss the clinical and molecular aspects of FMF in Arabs.

Original languageEnglish
Pages (from-to)1016-1024
Number of pages9
JournalLancet
Volume367
Issue number9515
DOIs
Publication statusPublished - 25 Mar 2006
Externally publishedYes

Fingerprint

Familial Mediterranean Fever
Hereditary Autoinflammatory Diseases
Inflammation
Jews
Amyloidosis
Ethnic Groups
Autoantibodies
Renal Insufficiency
Fever
T-Lymphocytes
Antigens
Mutation
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

El-Shanti, H., Majeed, H. A., & El-Khateeb, M. (2006). Familial Mediterranean fever in Arabs. Lancet, 367(9515), 1016-1024. https://doi.org/10.1016/S0140-6736(06)68430-4

Familial Mediterranean fever in Arabs. / El-Shanti, Hatem; Majeed, Hasan Abdel; El-Khateeb, Mohammed.

In: Lancet, Vol. 367, No. 9515, 25.03.2006, p. 1016-1024.

Research output: Contribution to journalArticle

El-Shanti, H, Majeed, HA & El-Khateeb, M 2006, 'Familial Mediterranean fever in Arabs', Lancet, vol. 367, no. 9515, pp. 1016-1024. https://doi.org/10.1016/S0140-6736(06)68430-4
El-Shanti H, Majeed HA, El-Khateeb M. Familial Mediterranean fever in Arabs. Lancet. 2006 Mar 25;367(9515):1016-1024. https://doi.org/10.1016/S0140-6736(06)68430-4
El-Shanti, Hatem ; Majeed, Hasan Abdel ; El-Khateeb, Mohammed. / Familial Mediterranean fever in Arabs. In: Lancet. 2006 ; Vol. 367, No. 9515. pp. 1016-1024.
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