Familial mediterranean fever and other autoinflammatory disorders

Hatem El-Shanti, Hasan Abdel Majeed

Research output: Chapter in Book/Report/Conference proceedingChapter


Autoinflammatory diseases are a group of disorders characterized by seemingly unprovoked inflammation in the absence of high-titer autoantibodies or antigen-specific T-cells (Stojanov and Kastner 2005). The autoinflammatory diseases include the hereditary periodic fever syndromes and are thought to be due to disturbances in the regulation of the innate immunity (Kastner 2005). Familial Mediterranean Fever (FMF) is the archetypal hereditary periodic fever syndrome and autoinflammatory disease. Other disorders include tumor necrosis factor receptor-associated periodic syndrome (TRAPS); hyperimmunoglobulinemia D with periodic fever syndrome (Hyper-IgD); pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome; the cryopyrinopathies: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also called chronic infantile neurologic cutaneous and articular syndrome, or CINCA syndrome); and chronic recurrent multifocal osteomyelitis (McGonagle and McDermott 2006; Milhavet et al. 2008).

Original languageEnglish
Title of host publicationGenetic Disorders Among Arab Populations
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages33
ISBN (Print)9783642050800, 9783642050794
Publication statusPublished - 2010


ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

El-Shanti, H., & Majeed, H. A. (2010). Familial mediterranean fever and other autoinflammatory disorders. In Genetic Disorders Among Arab Populations (pp. 111-143). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-05080-0_5