Familial history of stroke and stroke risk: The Family Heart Study

Duanping Liao, Richard Myers, Steven Hunt, Eyal Shahar, Catherine Paton, Gregory Burke, Michael Province, Gerardo Heiss

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Background and Purpose: Although familial history of stroke is generally perceived to be an important marker of stroke risk, very few epidemiological studies have been published to address this hypothesis. We sought to examine whether familial history of stroke is associated with the prevalence of stroke in the Family Heart Study, a National Heart, Lung, and Blood Institute-supported multicenter study of the familial, genetic, and nongenetic determinants of cardiovascular disease in populations. Methods: The personal and familial histories of stroke were assessed in 3168 individuals (probands) who were at least 45 years old and 29 325 of their first-degree relatives with the use of a standardized questionnaire. Results: The age-, ethnicity-, and sex-adjusted stroke prevalences were 4.8%, 4.9%, and 3.9% in probands with a positive familial, paternal, and maternal history of stroke, respectively, in comparison with 2.0% in probands without any positive familial history (P<.01). The age-, ethnicity-, and sex-adjusted odds ratios (95% confidence interval) of stroke were 2.00 (1.13, 3.54) for a positive paternal and 1.41 (0.80, 2.50) for a positive maternal history of stroke. Additional statistical adjustment for the proband's history of elevated cholesterol level, cigarette smoking status, history of coronary heart disease, hypertension, and diabetes did not alter the associations. A similar pattern was seen for African Americans and European Americans. Conclusions: The increased risk of stroke among persons with a positive familial history of stroke compared with those without a familial history of stroke is consistent with the expression of genetic susceptibility, a shared environment, or both in the etiology of stroke.

Original languageEnglish
Pages (from-to)1908-1912
Number of pages5
JournalStroke
Volume28
Issue number10
Publication statusPublished - Oct 1997
Externally publishedYes

Fingerprint

Stroke
Mothers
National Heart, Lung, and Blood Institute (U.S.)
Genetic Predisposition to Disease
Hypercholesterolemia
African Americans
Multicenter Studies
Coronary Disease
Epidemiologic Studies
Cardiovascular Diseases
Smoking
History
Odds Ratio
Confidence Intervals
Hypertension

Keywords

  • Epidemiology
  • Genetics
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Liao, D., Myers, R., Hunt, S., Shahar, E., Paton, C., Burke, G., ... Heiss, G. (1997). Familial history of stroke and stroke risk: The Family Heart Study. Stroke, 28(10), 1908-1912.

Familial history of stroke and stroke risk : The Family Heart Study. / Liao, Duanping; Myers, Richard; Hunt, Steven; Shahar, Eyal; Paton, Catherine; Burke, Gregory; Province, Michael; Heiss, Gerardo.

In: Stroke, Vol. 28, No. 10, 10.1997, p. 1908-1912.

Research output: Contribution to journalArticle

Liao, D, Myers, R, Hunt, S, Shahar, E, Paton, C, Burke, G, Province, M & Heiss, G 1997, 'Familial history of stroke and stroke risk: The Family Heart Study', Stroke, vol. 28, no. 10, pp. 1908-1912.
Liao D, Myers R, Hunt S, Shahar E, Paton C, Burke G et al. Familial history of stroke and stroke risk: The Family Heart Study. Stroke. 1997 Oct;28(10):1908-1912.
Liao, Duanping ; Myers, Richard ; Hunt, Steven ; Shahar, Eyal ; Paton, Catherine ; Burke, Gregory ; Province, Michael ; Heiss, Gerardo. / Familial history of stroke and stroke risk : The Family Heart Study. In: Stroke. 1997 ; Vol. 28, No. 10. pp. 1908-1912.
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AB - Background and Purpose: Although familial history of stroke is generally perceived to be an important marker of stroke risk, very few epidemiological studies have been published to address this hypothesis. We sought to examine whether familial history of stroke is associated with the prevalence of stroke in the Family Heart Study, a National Heart, Lung, and Blood Institute-supported multicenter study of the familial, genetic, and nongenetic determinants of cardiovascular disease in populations. Methods: The personal and familial histories of stroke were assessed in 3168 individuals (probands) who were at least 45 years old and 29 325 of their first-degree relatives with the use of a standardized questionnaire. Results: The age-, ethnicity-, and sex-adjusted stroke prevalences were 4.8%, 4.9%, and 3.9% in probands with a positive familial, paternal, and maternal history of stroke, respectively, in comparison with 2.0% in probands without any positive familial history (P<.01). The age-, ethnicity-, and sex-adjusted odds ratios (95% confidence interval) of stroke were 2.00 (1.13, 3.54) for a positive paternal and 1.41 (0.80, 2.50) for a positive maternal history of stroke. Additional statistical adjustment for the proband's history of elevated cholesterol level, cigarette smoking status, history of coronary heart disease, hypertension, and diabetes did not alter the associations. A similar pattern was seen for African Americans and European Americans. Conclusions: The increased risk of stroke among persons with a positive familial history of stroke compared with those without a familial history of stroke is consistent with the expression of genetic susceptibility, a shared environment, or both in the etiology of stroke.

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