Familial Dyslipidemic Hypertension

Evidence From 58 Utah Families for a Syndrome Present in Approximately 12% of Patients With Essential Hypertension

Roger R. Williams, Steven Hunt, Paul N. Hopkins, Barry M. Stults, Lily L. Mu, Sandra J. Hasstedt, Gary K. Barlow, Susan H. Stephenson, Jean Marc Lalouel, Hiroshi Kuida

Research output: Contribution to journalArticle

262 Citations (Scopus)

Abstract

Population-based sibships with essential hypertension diagnosed before the age of 60 years are being screened in Utah to find two or more hypertensive siblings with the same biochemical abnormality as a clue to an inherited cause for their specific type of hypertension. Among 131 hypertensive subjects in 58 sibships, concordant abnormalities in fasting serum lipid concentrations were observed in two or more siblings in 48% of the sibships. After adjusting for effects of antihypertensive medications, abnormal values reported in only 10% of the Lipid Research Clinics data were observed in 30% of patients for serum triglycerides, 19% for serum low-density lipoprotein cholesterol, and 39% for high-density lipoprotein cholesterol. More than one lipid level was abnormal in almost all concordant sibships, suggesting an association between hypertension and a syndrome of mixed lipid abnormalities, probably familial combined hyperlipidemia (renamed “familial combined dyslipidemia” because of common low high-density lipoprotein cholesterol levels). We conclude that familial dyslipidemic hypertension may be a specific syndrome with lipid abnormalities more severe than blood pressure elevations.

Original languageEnglish
Pages (from-to)3579-3586
Number of pages8
JournalJAMA: The Journal of the American Medical Association
Volume259
Issue number24
DOIs
Publication statusPublished - 24 Jun 1988
Externally publishedYes

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Hypertension
Lipids
LDL Cholesterol
HDL Cholesterol
Siblings
Familial Combined Hyperlipidemia
Serum
Dyslipidemias
Antihypertensive Agents
Fasting
Triglycerides
Essential Hypertension
Blood Pressure
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Familial Dyslipidemic Hypertension : Evidence From 58 Utah Families for a Syndrome Present in Approximately 12% of Patients With Essential Hypertension. / Williams, Roger R.; Hunt, Steven; Hopkins, Paul N.; Stults, Barry M.; Mu, Lily L.; Hasstedt, Sandra J.; Barlow, Gary K.; Stephenson, Susan H.; Lalouel, Jean Marc; Kuida, Hiroshi.

In: JAMA: The Journal of the American Medical Association, Vol. 259, No. 24, 24.06.1988, p. 3579-3586.

Research output: Contribution to journalArticle

Williams, Roger R. ; Hunt, Steven ; Hopkins, Paul N. ; Stults, Barry M. ; Mu, Lily L. ; Hasstedt, Sandra J. ; Barlow, Gary K. ; Stephenson, Susan H. ; Lalouel, Jean Marc ; Kuida, Hiroshi. / Familial Dyslipidemic Hypertension : Evidence From 58 Utah Families for a Syndrome Present in Approximately 12% of Patients With Essential Hypertension. In: JAMA: The Journal of the American Medical Association. 1988 ; Vol. 259, No. 24. pp. 3579-3586.
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