Familial dyslipidaemic hypertension and other multiple metabolic syndromes

Roger R. Williams, Paul N. Hopkins, Steven Hunt, M. Catherine Schumacher, Steven C. Elbein, Dana E. Wilson, Barry M. Stults, Lily L. Wu, Sandra J. Hasstedt, Jean Marc Lalouel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalAnnals of Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Hypertension
Hyperlipoproteinemia Type I
Familial Combined Hyperlipidemia
Metabolic Syndrome X
Prehypertension
Multiple Abnormalities
Glucose Intolerance
Abdominal Obesity
Coronary Disease
Obesity
Insulin
Diet
Lipids
Genes
oxidized low density lipoprotein

Keywords

  • Coronary heart disease
  • Diabetes
  • Dyslipidaemia
  • Familial combined hyperlipidaemia
  • Hyperinsulinaemia
  • Hypertension
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Williams, R. R., Hopkins, P. N., Hunt, S., Schumacher, M. C., Elbein, S. C., Wilson, D. E., ... Lalouel, J. M. (1992). Familial dyslipidaemic hypertension and other multiple metabolic syndromes. Annals of Medicine, 24(6), 469-475. https://doi.org/10.3109/07853899209166998

Familial dyslipidaemic hypertension and other multiple metabolic syndromes. / Williams, Roger R.; Hopkins, Paul N.; Hunt, Steven; Schumacher, M. Catherine; Elbein, Steven C.; Wilson, Dana E.; Stults, Barry M.; Wu, Lily L.; Hasstedt, Sandra J.; Lalouel, Jean Marc.

In: Annals of Medicine, Vol. 24, No. 6, 1992, p. 469-475.

Research output: Contribution to journalArticle

Williams, RR, Hopkins, PN, Hunt, S, Schumacher, MC, Elbein, SC, Wilson, DE, Stults, BM, Wu, LL, Hasstedt, SJ & Lalouel, JM 1992, 'Familial dyslipidaemic hypertension and other multiple metabolic syndromes', Annals of Medicine, vol. 24, no. 6, pp. 469-475. https://doi.org/10.3109/07853899209166998
Williams, Roger R. ; Hopkins, Paul N. ; Hunt, Steven ; Schumacher, M. Catherine ; Elbein, Steven C. ; Wilson, Dana E. ; Stults, Barry M. ; Wu, Lily L. ; Hasstedt, Sandra J. ; Lalouel, Jean Marc. / Familial dyslipidaemic hypertension and other multiple metabolic syndromes. In: Annals of Medicine. 1992 ; Vol. 24, No. 6. pp. 469-475.
@article{cb450fcc6c6b479caae10ee737ca4c50,
title = "Familial dyslipidaemic hypertension and other multiple metabolic syndromes",
abstract = "Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.",
keywords = "Coronary heart disease, Diabetes, Dyslipidaemia, Familial combined hyperlipidaemia, Hyperinsulinaemia, Hypertension, Lipoprotein lipase",
author = "Williams, {Roger R.} and Hopkins, {Paul N.} and Steven Hunt and Schumacher, {M. Catherine} and Elbein, {Steven C.} and Wilson, {Dana E.} and Stults, {Barry M.} and Wu, {Lily L.} and Hasstedt, {Sandra J.} and Lalouel, {Jean Marc}",
year = "1992",
doi = "10.3109/07853899209166998",
language = "English",
volume = "24",
pages = "469--475",
journal = "Annals of Medicine",
issn = "0785-3890",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Familial dyslipidaemic hypertension and other multiple metabolic syndromes

AU - Williams, Roger R.

AU - Hopkins, Paul N.

AU - Hunt, Steven

AU - Schumacher, M. Catherine

AU - Elbein, Steven C.

AU - Wilson, Dana E.

AU - Stults, Barry M.

AU - Wu, Lily L.

AU - Hasstedt, Sandra J.

AU - Lalouel, Jean Marc

PY - 1992

Y1 - 1992

N2 - Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.

AB - Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.

KW - Coronary heart disease

KW - Diabetes

KW - Dyslipidaemia

KW - Familial combined hyperlipidaemia

KW - Hyperinsulinaemia

KW - Hypertension

KW - Lipoprotein lipase

UR - http://www.scopus.com/inward/record.url?scp=0027092523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027092523&partnerID=8YFLogxK

U2 - 10.3109/07853899209166998

DO - 10.3109/07853899209166998

M3 - Article

VL - 24

SP - 469

EP - 475

JO - Annals of Medicine

JF - Annals of Medicine

SN - 0785-3890

IS - 6

ER -