Familial dyslipidaemic hypertension and other multiple metabolic syndromes

Roger R. Williams, Paul N. Hopkins, Steven Hunt, M. Catherine Schumacher, Steven C. Elbein, Dana E. Wilson, Barry M. Stults, Lily L. Wu, Sandra J. Hasstedt, Jean Marc Lalouel

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Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalAnnals of Medicine
Issue number6
Publication statusPublished - 1992
Externally publishedYes



  • Coronary heart disease
  • Diabetes
  • Dyslipidaemia
  • Familial combined hyperlipidaemia
  • Hyperinsulinaemia
  • Hypertension
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Williams, R. R., Hopkins, P. N., Hunt, S., Schumacher, M. C., Elbein, S. C., Wilson, D. E., Stults, B. M., Wu, L. L., Hasstedt, S. J., & Lalouel, J. M. (1992). Familial dyslipidaemic hypertension and other multiple metabolic syndromes. Annals of Medicine, 24(6), 469-475. https://doi.org/10.3109/07853899209166998