Factors in choosing atypical antipsychotics: Toward understanding the bases of physicians' prescribing decisions

Jennifer Hoblyn, Art Noda, Jerome A. Yesavage, John O. Brooks, Javaid Sheikh, Tina Lee, Jared R. Tinklenberg, Bret Schneider, Ruth O'Hara, Douglas L. Leslie, Robert A. Rosenheck, Helena C. Kraemer

Research output: Contribution to journalArticle

13 Citations (Scopus)


Objective: Off-label prescribing of medications, polypharmacy, and other questionable prescribing practices have led investigators to examine a large VA pharmacy database to determine if physician prescribing decisions appear reasonable. Method: The current study addresses the question of physician prescribing of atypical antipsychotics in 34,925 veterans with schizophrenia, using a series of signal detection analyses. Results: These results suggest that only three factors (hospital size, age, and secondary diagnosis) allow classification of patients prescribed atypicals into three groups with frequencies of use of atypicals ranging from 43% to 79%, and that these results are consistent with reasonable clinical practice. Conclusions: Results of two-stage signal detection analyses are readily interpretable by clinicians and administrators who are faced with the task of evaluating how physicians prescribe medications in clinical practice. Physicians' decisions to prescribe atypical antipsychotics are based on both patient and fiscal considerations. This likely reflects a combination of clinical judgment and institutional guidelines.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalJournal of Psychiatric Research
Issue number2
Publication statusPublished - Mar 2006
Externally publishedYes



  • Age
  • Logistic regression
  • MeSH antipsychotics
  • Schizophrenia
  • Signal detection

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Hoblyn, J., Noda, A., Yesavage, J. A., Brooks, J. O., Sheikh, J., Lee, T., Tinklenberg, J. R., Schneider, B., O'Hara, R., Leslie, D. L., Rosenheck, R. A., & Kraemer, H. C. (2006). Factors in choosing atypical antipsychotics: Toward understanding the bases of physicians' prescribing decisions. Journal of Psychiatric Research, 40(2), 160-166. https://doi.org/10.1016/j.jpsychires.2005.06.004