Facile synthesis of steroidal primary amides via palladium-catalyzed aminocarbonylation of steroidal alkenyl halides

János Balogh, Sándor Mahó, Viktor Háda, László Kollár, Rita Skoda-Földes

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A new method for the synthesis of primary amides from alkenyl iodides in one carbonylation step using ammonium carbamate as ammonia synthon is reported. The products were obtained in good yields under mild reaction conditions using CO (1-6 bar). Steroidal substrates with various moieties (e.g., 6-OH group, lactams, or aromatic A-ring) could be converted selectively into the products.

Original languageEnglish
Article numberT03808SS
Pages (from-to)3040-3042
Number of pages3
JournalSynthesis
Issue number19
DOIs
Publication statusPublished - 1 Oct 2008
Externally publishedYes

Fingerprint

Carbonylation
Lactams
Palladium
Iodides
Carbon Monoxide
Amides
Ammonia
Substrates
carbamic acid

Keywords

  • Carbonylations
  • Homogeneous catalysis
  • Palladium
  • Primary amides
  • Steroids

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

Cite this

Facile synthesis of steroidal primary amides via palladium-catalyzed aminocarbonylation of steroidal alkenyl halides. / Balogh, János; Mahó, Sándor; Háda, Viktor; Kollár, László; Skoda-Földes, Rita.

In: Synthesis, No. 19, T03808SS, 01.10.2008, p. 3040-3042.

Research output: Contribution to journalArticle

Balogh, János ; Mahó, Sándor ; Háda, Viktor ; Kollár, László ; Skoda-Földes, Rita. / Facile synthesis of steroidal primary amides via palladium-catalyzed aminocarbonylation of steroidal alkenyl halides. In: Synthesis. 2008 ; No. 19. pp. 3040-3042.
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