Extracellular vesicles-mediated intercellular communication: Roles in the tumor microenvironment and anti-cancer drug resistance

Selma Maacha, Ajaz Ahmad Bhat, Lizandra Jimenez, Afsheen Raza, Mohammad Haris, Shahab Uddin, Jean-Charles B. Grivel

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor microenvironment in supporting tumor phenotype via a sophisticated system of intercellular communication through direct cell-to-cell contact or by classical paracrine signaling loops of cytokines or growth factors. Recently, extracellular vesicles have emerged as an important mechanism of cellular interchange of bioactive molecules. Extracellular vesicles isolated from tumor and stromal cells have been implicated in various steps of tumor progression, such as proliferation, angiogenesis, metastasis, and drug resistance. Inhibition of extracellular vesicles secretion, and thus of the transfer of oncogenic molecules, holds promise for preventing tumor growth and drug resistance. This review focuses on the role of extracellular vesicles in modulating the tumor microenvironment by addressing different aspects of the bidirectional interactions among tumor and tumor-associated cells. The contribution of extracellular vesicles to drug resistance will also be discussed as well as therapeutic strategies targeting extracellular vesicles production for the treatment of cancer.

Original languageEnglish
Article number55
JournalMolecular cancer
Volume18
Issue number1
DOIs
Publication statusPublished - 30 Mar 2019

Fingerprint

Tumor Microenvironment
Drug Resistance
Neoplasms
Stromal Cells
Paracrine Communication
Extracellular Vesicles
Intercellular Signaling Peptides and Proteins
Cytokines
Neoplasm Metastasis
Phenotype
Growth
Research

Keywords

  • Drug resistance
  • Extracellular vesicles
  • Metastasis
  • Stroma
  • Tumor microenvironment

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Cite this

Extracellular vesicles-mediated intercellular communication : Roles in the tumor microenvironment and anti-cancer drug resistance. / Maacha, Selma; Bhat, Ajaz Ahmad; Jimenez, Lizandra; Raza, Afsheen; Haris, Mohammad; Uddin, Shahab; Grivel, Jean-Charles B.

In: Molecular cancer, Vol. 18, No. 1, 55, 30.03.2019.

Research output: Contribution to journalReview article

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