Extracellular pH modulates aluminium-blockade of mammalian voltage-activated calcium channel currents

Bettina Platt, Helmut Haas, Dietrich Busselberg

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18 Citations (Scopus)

Abstract

The pH-dependence of aluminium (Al) blockade of voltage activated calcium channels (VACCs) was investigated. Using cultures of rat dorsal root ganglion (DRG) neurones, whole-cell patch-clamp experiments were performed. Various concentrations of Al were extracellularly applied within solutions of different pH-values. The block of VACC currents was highly pH-dependent. At pH 7.3-7.8, the concentration-response curve shifted slightly to higher concentrations, whereas at pH 6.4-6.9 a pronounced shift to lower concentrations was observed. This effect could be due to changes of the chemical equilibria of the different Al species or to altered properties of the VACCs. Thus, pH-shifts may influence the interactions of Al with VACCs making them more susceptible to the effects of Al and therefore contribute to its toxicity.

Original languageEnglish
Pages (from-to)1251-1254
Number of pages4
JournalNeuroReport
Volume4
Issue number11
Publication statusPublished - 10 Sep 1993
Externally publishedYes

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Keywords

  • Aluminium (Al)
  • Dorsal root ganglia (DRG)
  • pH-dependence
  • Voltage activated calcium channels (VACC)

ASJC Scopus subject areas

  • Neuroscience(all)

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