Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer

Christophe M. Raynaud, Olaf Mercier, Philippe Dartevelle, Frédéric Commo, Ken André Olaussen, Vincent De Montpreville, Fabrice André, Laure Sabatier, Jean Charles Soria

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16 Citations (Scopus)

Abstract

Background: Recent studies suggest that chemokines are involved in organ-specific metastatic relapse. We evaluated the potential implications of chemokine receptors in the development of adrenal metastasis after complete resections of primary non-small-cell lung cancer. Patients and Methods: We studied a unique cohort of 21 primary lung cancers with matched adrenal metastases for the expression of CX3CR1, CXCR4, CCR6, and CCR7, using immunohistochemistry. Results: Although CXCR4, CX3CR1, and CCR7 were independently expressed in primary and corresponding metastases, CCR6 was clearly overexpressed in adrenal metastases, compared with corresponding primary tumors. Moreover, CCL20, the ligand of CCR6, was preferentially expressed in adrenal tissues that developed metastases. Conclusion: We report for the first time (to the best of our knowledge) a potential role for the CCR6 receptor in the organ orientation of the development of metastases in lung cancer. We demonstrated a statistically significant overexpression of CCR6 in adrenal metastases compared with primary lung tumors, indicating that the increased production of CCL20 in adrenal glands might contribute to the selective recruitment of CCR6-expressing cancer cells in lung cancer. This study, in concordance with the data obtained in animal models, suggests that the chemokine receptor family constitutes a biologic support of the "seed and soil" theory.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalClinical Lung Cancer
Volume11
Issue number3
DOIs
Publication statusPublished - May 2010

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Keywords

  • Adrenal gland homing
  • Adrenal metastases
  • CCL20
  • Lymphatic vessel invasion
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Raynaud, C. M., Mercier, O., Dartevelle, P., Commo, F., Olaussen, K. A., De Montpreville, V., André, F., Sabatier, L., & Soria, J. C. (2010). Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer. Clinical Lung Cancer, 11(3), 187-191. https://doi.org/10.3816/CLC.2010.n.024