Experience with liver dialysis in acetaminophen induced fulminant hepatic failure

A preliminary report

Meral Akdoǧan, Karim El-Sahwi, Urooj Ahmed, Samy Rashwan, Anthony Sebastian, Harlan Wright, Bakr Nour, Ahmet Gürakar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/aims: Our aim was to assess the efficacy of the liver dialysis unit (LDU) in the treatment of patients with acetaminophen-induced fulminant hepatic failure. Methods: Seventeen patients with acetaminophen-induced fulminant hepatic failure between January 1996 and December 2001 were retrospectively studied. A liver dialysis unit became available in our Unit in July 2000, and as of December 2001, four of these 17 patients had undergone treatment with liver dialysis. Results: Mean age was 29 years (range: 14-47) and 76% were women. Four of 17 patients underwent a total of 12 (range: 1-4) LDU sessions. Ammonia level tended to be lower following the LDU and all four patients recovered without a need for orthotopic liver transplantation (OLT). Prior to July 2000, eight of 13 patients survived with supportive therapy, three expired and two underwent OLT. No major bleeding episodes were observed during the LDU course. A significant difference was found between the three cases who died and the cases that survived with respect to the grade of encephalopathy (p<0.001). There was significant difference in the admission serum creatinine among survivors (p<0.05). Conclusion: In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalTurkish Journal of Gastroenterology
Volume14
Issue number3
Publication statusPublished - Sep 2003
Externally publishedYes

Fingerprint

Acute Liver Failure
Acetaminophen
Dialysis
Liver
Brain Diseases
Liver Transplantation
Therapeutics
Ammonia
Survivors
Creatinine
Hemorrhage
Serum

Keywords

  • Acetaminophen toxicity
  • Fulminant hepatic failure
  • Liver dialysis unit

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Akdoǧan, M., El-Sahwi, K., Ahmed, U., Rashwan, S., Sebastian, A., Wright, H., ... Gürakar, A. (2003). Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: A preliminary report. Turkish Journal of Gastroenterology, 14(3), 164-167.

Experience with liver dialysis in acetaminophen induced fulminant hepatic failure : A preliminary report. / Akdoǧan, Meral; El-Sahwi, Karim; Ahmed, Urooj; Rashwan, Samy; Sebastian, Anthony; Wright, Harlan; Nour, Bakr; Gürakar, Ahmet.

In: Turkish Journal of Gastroenterology, Vol. 14, No. 3, 09.2003, p. 164-167.

Research output: Contribution to journalArticle

Akdoǧan, M, El-Sahwi, K, Ahmed, U, Rashwan, S, Sebastian, A, Wright, H, Nour, B & Gürakar, A 2003, 'Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: A preliminary report', Turkish Journal of Gastroenterology, vol. 14, no. 3, pp. 164-167.
Akdoǧan M, El-Sahwi K, Ahmed U, Rashwan S, Sebastian A, Wright H et al. Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: A preliminary report. Turkish Journal of Gastroenterology. 2003 Sep;14(3):164-167.
Akdoǧan, Meral ; El-Sahwi, Karim ; Ahmed, Urooj ; Rashwan, Samy ; Sebastian, Anthony ; Wright, Harlan ; Nour, Bakr ; Gürakar, Ahmet. / Experience with liver dialysis in acetaminophen induced fulminant hepatic failure : A preliminary report. In: Turkish Journal of Gastroenterology. 2003 ; Vol. 14, No. 3. pp. 164-167.
@article{99a2058bd5b54cbfbd4db71e4ad1942f,
title = "Experience with liver dialysis in acetaminophen induced fulminant hepatic failure: A preliminary report",
abstract = "Background/aims: Our aim was to assess the efficacy of the liver dialysis unit (LDU) in the treatment of patients with acetaminophen-induced fulminant hepatic failure. Methods: Seventeen patients with acetaminophen-induced fulminant hepatic failure between January 1996 and December 2001 were retrospectively studied. A liver dialysis unit became available in our Unit in July 2000, and as of December 2001, four of these 17 patients had undergone treatment with liver dialysis. Results: Mean age was 29 years (range: 14-47) and 76{\%} were women. Four of 17 patients underwent a total of 12 (range: 1-4) LDU sessions. Ammonia level tended to be lower following the LDU and all four patients recovered without a need for orthotopic liver transplantation (OLT). Prior to July 2000, eight of 13 patients survived with supportive therapy, three expired and two underwent OLT. No major bleeding episodes were observed during the LDU course. A significant difference was found between the three cases who died and the cases that survived with respect to the grade of encephalopathy (p<0.001). There was significant difference in the admission serum creatinine among survivors (p<0.05). Conclusion: In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients.",
keywords = "Acetaminophen toxicity, Fulminant hepatic failure, Liver dialysis unit",
author = "Meral Akdoǧan and Karim El-Sahwi and Urooj Ahmed and Samy Rashwan and Anthony Sebastian and Harlan Wright and Bakr Nour and Ahmet G{\"u}rakar",
year = "2003",
month = "9",
language = "English",
volume = "14",
pages = "164--167",
journal = "Turkish Journal of Gastroenterology",
issn = "1300-4948",
publisher = "Turkish Society of Gastroenterology",
number = "3",

}

TY - JOUR

T1 - Experience with liver dialysis in acetaminophen induced fulminant hepatic failure

T2 - A preliminary report

AU - Akdoǧan, Meral

AU - El-Sahwi, Karim

AU - Ahmed, Urooj

AU - Rashwan, Samy

AU - Sebastian, Anthony

AU - Wright, Harlan

AU - Nour, Bakr

AU - Gürakar, Ahmet

PY - 2003/9

Y1 - 2003/9

N2 - Background/aims: Our aim was to assess the efficacy of the liver dialysis unit (LDU) in the treatment of patients with acetaminophen-induced fulminant hepatic failure. Methods: Seventeen patients with acetaminophen-induced fulminant hepatic failure between January 1996 and December 2001 were retrospectively studied. A liver dialysis unit became available in our Unit in July 2000, and as of December 2001, four of these 17 patients had undergone treatment with liver dialysis. Results: Mean age was 29 years (range: 14-47) and 76% were women. Four of 17 patients underwent a total of 12 (range: 1-4) LDU sessions. Ammonia level tended to be lower following the LDU and all four patients recovered without a need for orthotopic liver transplantation (OLT). Prior to July 2000, eight of 13 patients survived with supportive therapy, three expired and two underwent OLT. No major bleeding episodes were observed during the LDU course. A significant difference was found between the three cases who died and the cases that survived with respect to the grade of encephalopathy (p<0.001). There was significant difference in the admission serum creatinine among survivors (p<0.05). Conclusion: In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients.

AB - Background/aims: Our aim was to assess the efficacy of the liver dialysis unit (LDU) in the treatment of patients with acetaminophen-induced fulminant hepatic failure. Methods: Seventeen patients with acetaminophen-induced fulminant hepatic failure between January 1996 and December 2001 were retrospectively studied. A liver dialysis unit became available in our Unit in July 2000, and as of December 2001, four of these 17 patients had undergone treatment with liver dialysis. Results: Mean age was 29 years (range: 14-47) and 76% were women. Four of 17 patients underwent a total of 12 (range: 1-4) LDU sessions. Ammonia level tended to be lower following the LDU and all four patients recovered without a need for orthotopic liver transplantation (OLT). Prior to July 2000, eight of 13 patients survived with supportive therapy, three expired and two underwent OLT. No major bleeding episodes were observed during the LDU course. A significant difference was found between the three cases who died and the cases that survived with respect to the grade of encephalopathy (p<0.001). There was significant difference in the admission serum creatinine among survivors (p<0.05). Conclusion: In conclusion, the Liver Dialysis Unit treatment appeared to benefit patients with acetaminophen-induced fulminant hepatic failure by reverse of the encephalopathy and spontaneous recovery of the damaged liver in selected patients.

KW - Acetaminophen toxicity

KW - Fulminant hepatic failure

KW - Liver dialysis unit

UR - http://www.scopus.com/inward/record.url?scp=17444450351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17444450351&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 164

EP - 167

JO - Turkish Journal of Gastroenterology

JF - Turkish Journal of Gastroenterology

SN - 1300-4948

IS - 3

ER -