Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Leiluo Geng, Boya Liao, Leigang Jin, Zhe Huang, Christopher Triggle, Hong Ding, Jialiang Zhang, Yu Huang, Zhuofeng Lin, Aimin Xu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.

Original languageEnglish
Pages (from-to)2738-2752.e4
JournalCell Reports
Volume26
Issue number10
DOIs
Publication statusPublished - 5 Mar 2019

Fingerprint

Adipose Tissue
Obesity
Tissue
Crosstalk
Transducers
Lipid Metabolism
Insulin Resistance
Homeostasis
Insulin
Glucose
fibroblast growth factor 21

Keywords

  • adipokines
  • adipose tissue
  • exercise
  • FGF21
  • FGFR1
  • KLB
  • metabolic regulation
  • obesity
  • PPARγ

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. / Geng, Leiluo; Liao, Boya; Jin, Leigang; Huang, Zhe; Triggle, Christopher; Ding, Hong; Zhang, Jialiang; Huang, Yu; Lin, Zhuofeng; Xu, Aimin.

In: Cell Reports, Vol. 26, No. 10, 05.03.2019, p. 2738-2752.e4.

Research output: Contribution to journalArticle

Geng, Leiluo ; Liao, Boya ; Jin, Leigang ; Huang, Zhe ; Triggle, Christopher ; Ding, Hong ; Zhang, Jialiang ; Huang, Yu ; Lin, Zhuofeng ; Xu, Aimin. / Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. In: Cell Reports. 2019 ; Vol. 26, No. 10. pp. 2738-2752.e4.
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